Heparin-binding protein in ventilator-induced lung injury

Intensive Care Medicine Experimental

Table 2 Levels of heparin-binding protein and neutrophil counts in pigs subjected to injurious ventilation and controls

Baseline	HBP in BALF (ng/ml)			HBP in plasma (ng/ml)			Neutrophil count in BALF (×10⁴/ml)
Baseline	Control	VILI	p	Control	VILI	p	Control	VILI	p
	45 (32–216)	17 (14–18)	0.01	23 (16–29)	21 (20–25)	0.84	1.1 (0.5–2.0)	0.9 (0.2–1.4)	0.49
1 h	20 (18–23)	29 (20–43)	0.04*	31 (21–58)	23 (19–34)	0.70	1.0 (0.7–1.2)	1.4 (0.8–2.5)	0.39
2 h	25 (19–42)	147 (62–453)	0.03*	25 (18–31)	24 (18–36)	0.69	1.3 (0.6–2.2)	6.3 (4.6–12.6)	< 0.01*
4 h	22 (17–235)	859 (250–1475)	< 0.01*	28 (24–39)	35 (23–39)	0.94	1.7 (0.8–4.1)	22.1 (6.6–28.2)	0.05
6 h	89 (33–191)	1144 (359–1636)	0.02*	33 (31–44)	61 (47–77)	0.13	2.7 (2.2–2.8)	21.0 (6.1–33.7)	0.03*

Data are presented as the median (interquartile range). Asterisks indicate statistical significance (p < 0.05)
HBP heparin-binding protein, BALF bronchoalveolar lavage fluid, VILI ventilator-induced lung injury