Intensive Care Medicine Experimental

Table 4 Details of ventilatory management before and during ECMO

From: Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Study	Ventilator strategy										Gas exchange targets
	Before ECMO					During ECMO					Before ECMO			During ECMO
	Mode	Vt	PEEP	RR	FiO₂	Mode	Vt	PEEP	RR	FiO₂	PaO₂	SpO₂	PaCO₂	PaO₂	SpO₂	PaCO₂
		mL/kg	cmH₂O	b/min			mL/kg	cmH₂O	b/min		mmHg		mmHg	mmHg		mmHg
Dogs
Kim et al. [18]					0.4						150–250		35–45
Pigs
Araos et al. [12]	VC	10	5	16–18	1.0	VC	10	5	nPaCO₂				35–50			30–50
Wang et al. [28]	PC	7–9	0	30	0.21–0.30	PC	7–9	2–4	20–25	0.3–0.5						35–45
Ni et al. [23]						VC	8	5	15	0.5
Pilarczyk et al. [25]	PC	6	5	15	1.0
Park et al. [24]		8	5	nPaCO₂	1.0			VAR				94–96	35–45	VAR	VAR	VAR
Kopp et al. [20]				nPaCO₂	1.0					0.2
Song et al. [26]	PC	7–9	0	30	0.21–0.35	PC		2–4	10–30	0.21–0.5	> 60		35–45	> 60		35–45
Kopp et al. [21]		10	5	nPaCO₂	1.0	PC	6–8	8		VAR			NORM	60–80		NORM
Henderson et al. [16]		10–15	5	10	0.4								NORM	200–300		35–45
Dembinski et al. [13]	VC	8	5	nPaCO₂	1.0								NORM
Sheep
Kocyildrim et al. [19]		10		12–15	0.6		6–7	5	10–12	0.21			35–40
Hou et al. [17]		6–8		16–18			6–8		16–18
Langer et al. [22]	CPAP	VAR	8	VAR	0.5	CPAP	VAR	8	VAR	0.5						VAR
Shekar et al. [14]						VC	4–6	10	6	0.21
Totapally et al. [27]		7	4	nPaCO₂	1	CMV			VAR				35–45			35–45
Germann et al. [15]	PC		0–10		0.3–0.7						> 70

Vt tidal volume, PEEP positive end expiratory pressure, RR respiratory rate, FiO₂ inspired fraction of oxygen, PaO₂ arterial partial pressure of oxygen, SpO₂ peripheral oxygen saturation, PaCO₂ arterial partial pressure of carbon dioxide, nPaCO₂ to maintain PaCO₂ in normal range, VC volume controlled, PC pressure controlled, CPAP continuous positive airway pressure, NORM to ‘normal range’, VAR varied

Back to article page