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Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns

Fig. 2

A comparison of the imaging techniques for analysing biodistribution. a MRI scan revealing detailed anatomical structure but poor distinction between air-tissue interface and SPIO radiolabel [123]. b PET detection of IV administered radiolabelled MSCs showing good resolution with no anatomical structure [124]. c Gamma camera acquisition of radiolabelled IV administered cells demonstrating lower resolution than PET and no anatomical structure [125]. d BLI detection of luciferase reporter-labelled MSCs administered IV demonstrating a lower sensitivity than PET/SPECT and external anatomical structure alluding to in vivo cell location [126]. e, f Intravital microscopy imaging of live tissues demonstrating the specificity of labelling at the cellular level (pulmonary tissue; cytoplasm = red, nuclei = green) [127]. g GFP-labelled MSCs detected in lung tissue sections (green) with cell nuclei clearly visible (blue) [128]. h The use of the CryoViz® system offers the 3D reconstruction of histological sections containing MSCs labelled using Q dots [71]

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