Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury

Intensive Care Medicine Experimental

Table 1 Physiological parameters of the two-hit lung injury model

Intervention group	MAP (mmHg)			pH			Lactate (mmol/L)			P_insp (mbar)
Intervention group	T = 2	T = 4	T = 6	T = 2	T = 4	T = 6	T = 2	T = 4	T = 6	T = 2	T = 4	T = 6
Hit	116	102	80	7.53	7.56	7.50	6.97	4.42	4.73	18	18	18
AT	112	92	77	7.57	7.62	7.59	6.05	4.61	4.65	20	20	21
A1PI	109	90	77	7.55	7.60	7.53	6.93	4.80	5.22	20	20	21
AT + A1PI	114	98	89	7.58	7.59	7.57	6.33	5.07	5.57	19	20	21
AT + A1PI + heparin	106	96	78	7.52	7.60	7.57	6.29	5.11	4.18	21	20	20

Abbreviations: AT antithrombin, A1PI alpha-1 protease inhibitor, MAP mean arterial pressure, Pinsp inspiratory pressure, T time point in h