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Table 3 Organ injury and inflammation

From: Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

ParameterStandard PLT doseHigh PLT dose
Before injuryAfter 6 hBefore injuryAfter 6 h
Respiratory
 PF-ratio (mmHg)507 (487–561)552 (372–621)521 (478–553)602 (517–620)
Coagulation
 Platelets (109/L)*877 (876–907)419 (125–629)1008 (946–1064)675 (185–739)#
 Fibrinogen (g/L)1.5 (0.9–1.7)1.3 (0.3–1.4)1.6 (1.5–1.7)1.7 (1.7–1.9)*
 LDH (U/L)129 (65–272)519 (156–1179)117 (80–211)452 (261–1653)#
Liver
 AST (U/L)63 (60–68)277 (152–385)66 (64–75)332 (216–390)#
 ALT (U/L)55 (50–59)168 (107–2613)#57 (50–61)146 (110–546)#
Kidney
 Creatinine (μmol/L)25 (21–28)103 (49–162)#24 (22–26)73 (42–136)#
 Urine protein (g/L)0.27 (0.08–0.55)4.44 (2.40–11.09)0.17 (0.10–0.33)2.08 (1.68–3.24)#
Inflammation
 Leukocytes (109/L)*7.1 (4.4–7.7)5.4 (5.2–6.6)7.1 (4.4–7.7)6.3 (4.9–7.7)
 IL-6 (pg/mL)< 4.1< 4.1< 4.1< 4.1
 IL-8 (pg/mL)< 31.25< 31.25< 31.25< 31.25
 HMGB-1 (pg/mL)402 (390–481)689 (416–1877)#380 (353–424)659 (589–1276)#
  1. Data are presented as median (IQR)
  2. PLT platelet transfusion, PF PaO2/FiO2, PT prothrombin time, AST aspartate aminotransferase, ALT alanine transaminase, LDH lactate dehydrogenase, IL-6 interleukin-6, IL-8 interleukin-8, and HMGB-1 high mobility group box 1
  3. *p < 0.050 for differences between groups. #p < 0.050 for differences before and after 6 h within group