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Table 3 Organ injury and inflammation

From: Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model

Parameter

Standard PLT dose

High PLT dose

Before injury

After 6 h

Before injury

After 6 h

Respiratory

 PF-ratio (mmHg)

507 (487–561)

552 (372–621)

521 (478–553)

602 (517–620)

Coagulation

 Platelets (109/L)*

877 (876–907)

419 (125–629)

1008 (946–1064)

675 (185–739)#

 Fibrinogen (g/L)

1.5 (0.9–1.7)

1.3 (0.3–1.4)

1.6 (1.5–1.7)

1.7 (1.7–1.9)*

 LDH (U/L)

129 (65–272)

519 (156–1179)

117 (80–211)

452 (261–1653)#

Liver

 AST (U/L)

63 (60–68)

277 (152–385)

66 (64–75)

332 (216–390)#

 ALT (U/L)

55 (50–59)

168 (107–2613)#

57 (50–61)

146 (110–546)#

Kidney

 Creatinine (μmol/L)

25 (21–28)

103 (49–162)#

24 (22–26)

73 (42–136)#

 Urine protein (g/L)

0.27 (0.08–0.55)

4.44 (2.40–11.09)

0.17 (0.10–0.33)

2.08 (1.68–3.24)#

Inflammation

 Leukocytes (109/L)*

7.1 (4.4–7.7)

5.4 (5.2–6.6)

7.1 (4.4–7.7)

6.3 (4.9–7.7)

 IL-6 (pg/mL)

< 4.1

< 4.1

< 4.1

< 4.1

 IL-8 (pg/mL)

< 31.25

< 31.25

< 31.25

< 31.25

 HMGB-1 (pg/mL)

402 (390–481)

689 (416–1877)#

380 (353–424)

659 (589–1276)#

  1. Data are presented as median (IQR)
  2. PLT platelet transfusion, PF PaO2/FiO2, PT prothrombin time, AST aspartate aminotransferase, ALT alanine transaminase, LDH lactate dehydrogenase, IL-6 interleukin-6, IL-8 interleukin-8, and HMGB-1 high mobility group box 1
  3. *p < 0.050 for differences between groups. #p < 0.050 for differences before and after 6 h within group