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Intensive Care Medicine Experimental
Fig. 5 | Intensive Care Medicine Experimental

Fig. 5

From: Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Fig. 5

Simulation results of model V2 for treatment with PD-1/PD-L1 checkpoint blockers at different time points during sepsis. Blue, red, and black lines indicate myeloid cells (M), lymphocytes (L), and pathogen (P), respectively. Vertical straight lines indicate the time at which immunotherapy is administered: a 400 h; b 300 h; c 200 h; d 100 h

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