Fig. 3

KEGG-pathways associated with down-regulated genes after cecal ligation and puncture and back-regulated by landiolol infusion. a Venn diagram associated with the 1591 down-regulated genes in CLP group and the 603 up-regulated genes in CLP plus landiolol group in males. The 247 common genes represent regulated genes with a characteristic V form, down-regulated in sepsis and back-regulated by landiolol infusion. No significant biological processes were found associated to these 247 common genes. The table presents KEGG-pathways in which at least three of these 247 common genes are involved. Genes associated with the JAK/STAT pathway, BCL2 and AOX, and with the adrenergic pathway, PLCB4, TUBA8 and MYH7B, are highlighted in grey. b Venn diagram associated with the 761 down-regulated genes in CLP group and the 71 up-regulated genes in CLP plus landiolol group in females. Note that only 71 genes were up-regulated in the CLP plus landiolol group and that only 15 of them were back-regulated. No biological processes were found associated to these 15 common genes presented in the table; four genes are members of specific KEGG-pathways and the others are isolated genes. CLP cecal ligation and puncture, CLP + Lnd CLP plus landiolol