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Intensive Care Medicine Experimental
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model

Fig. 1

Cardiovascular vital sign trends and fluid Resuscitation. Trends in cardiovascular vital signs in relation to interventions. a–d NHP1–4, respectively. HR (measured in beats per minute) and MAP (measured in mmHg) are plotted on the left Y-axis. The vertical dashed line in a, b, and d represents the first detection of viremia (for NHP3 (c), first detection occurred earlier than this time scale). The vertical lines labeled “A” and “B” in those same panels represent the start of the first and second vasoactive medications, respectively. Cyan-shaded areas represent compensated shock while magenta-shaded areas represent decompensating shock. The vertical blue bars denote fluid rate in mL/kg/hour; bars significantly above the baseline represent fluid boluses. The initial high heart rate for NHP1 (a) is secondary to acidosis. Once the acidosis began to resolve, the heart rate stabilized until the onset of EVD-related illness

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