Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Schouten, Laura R. A.; Bos, Lieuwe D. J.; Serpa Neto, A.; van Vught, Lonneke A.; Wiewel, Maryse A.; Hoogendijk, Arie J.; Bonten, Marc J. M.; Cremer, Olaf L.; Horn, Janneke; van der Poll, Tom; Schultz, Marcus J.; Wösten-van Asperen, Roelie M.

doi:10.1186/s40635-019-0270-1

Intensive Care Medicine Experimental

Table 1 Characteristics of the ARDS patients

From: Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

	Young adults (n = 209)		Middle-aged adults (n = 213)		Elderly (n = 196)		p value
Demographics
Age (years), Median [IQR]	44	[36, 50]	61	[58, 64]	74	[71, 77]	NA
Male, n/total n (%)	119/209	(57)	135/213	(63)	134/196	(68)	0.060
Race, Caucasian, n/total n (%)	165/201	(82)	190/208	(91)	188/191	(98)	0.000
Admission
Admission type, medical, n/total n (%)	160/209	(77)	142/213	(67)	129/196	(66)	0.037
Readmission, n/total n (%)	22/209	(11)	27/213	(13)	31/196	(16)	0.285
Charlson Comorbidity Index, Median [IQR]	0	[0, 2]	0	[0, 2]	0	[0, 2]	0.288
APACHE-IV score, median [IQR]	76	[58, 101]	80	[61, 104]	85	[67, 102]	0.014
APACHE-IV score adjusted for age, median [IQR]	73	[56, 100]	67	[50, 90]	68	[50, 85]	0.150
Lung injury prediction score, median [IQR]	9	[7, 10]	9	[7, 10]	8	[7, 10]	0.472
ARDS diagnosis
Direct hit for ARDS^*, n/total n (%)	142/208	(68)	137/211	(65)	125/192	(65)	0.619
Berlin classification
Mild, n/total n (%)	84/209	(40)	78/213	(37)	84/196	(43)	0.409
Moderate, n/total n (%)	98/209	(47)	97/213	(46)	87/196	(44)	0.876
Severe, n/total n (%)	27/209	(13)	38/213	(18)	25/196	(13)	0.248
ARDS on admission, n/total n (%)	165/209	(79)	153/213	(72)	157/196	(80)	0.089
Time to ARDS from ICU admission, median [IQR]	0	[0, 1]	0	[0, 2]	0	[0, 1]	0.163
Organ failure
SOFA score at onset of ARDS, median [IQR]	8	[5, 11]	8	[6, 11]	8	[6, 10]	0.768
Acute kidney injury during admission, n/total n (%)	106/209	(51)	122/213	(57)	123/196	(63)	0.054
Ventilation and oxygenation at onset of ARDS
Tidal volume per PBW, median [IQR]	7.1	[6.2, 8.2]	7.2	[6.3–9.0]	7.1	[6.3, 8.1]	0.357
PEEP (cmH₂O), median [IQR]	10	[8, 14]	10	[8, 12]	8	[6, 12]	0.025
Inspiratory peak pressure (cmH₂O), median [IQR]	27	[20, 33]	25	[19, 31]	24	[19, 30]	0.036
PaO₂ FiO₂ ratio, median [IQR]	171	[121, 219]	160	[106, 216]	164	[120, 223]	0.432

SOFA sequential organ failure assessment, IQR interquartile range, APACHE Acute Physiology and Chronic Health Evaluation, PBW predicted body weight, PEEP positive end-expiratory pressure, NA not applicable. A p value < 0.05 was considered as statistically significant. ^*Supplementary data provides a table with detailed data on predisposing factors (see online Additional file 1: Table S1)

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