Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Schouten, Laura R. A.; Bos, Lieuwe D. J.; Serpa Neto, A.; van Vught, Lonneke A.; Wiewel, Maryse A.; Hoogendijk, Arie J.; Bonten, Marc J. M.; Cremer, Olaf L.; Horn, Janneke; van der Poll, Tom; Schultz, Marcus J.; Wösten-van Asperen, Roelie M.

doi:10.1186/s40635-019-0270-1

Intensive Care Medicine Experimental

Table 3 Association between age and inflammatory marker levels in ARDS patients (mediation step 3)

From: Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

	Coefficient [95% CI]	p value	Coefficient [95% CI]^*	p value	Adjusted R²
IL-6
Young adults	Reference	NA	Reference	NA	0.152
Middle-aged adults	− 0.33 [− 0.73, 0.08]	0.113	− 0.30 [− 0.69, 0.06]	0.117
Elderly	− 0.40 [− 0.81, 0.01]	0.057	− 0.33 [− 0.73, 0.06]	0.100
IL-8
Young adults	Reference	NA	Reference	NA	0.247
Middle-aged adults	− 019 [− 0.54, 0.16]	0.478	− 0.06 [− 0.37, 0.26]	0.767
Elderly	− 0.48 [− 0.84, − 0.12]	0.019	− 0.25 [− 0.58, 0.07]	0.148
IL-10
Young adults	Reference	NA	Reference	NA	0.203
Middle-aged adults	− 0.30 [− 0.62, 1.02]	0.174	− 0.21 [− 0.51, 0.08]	0.133
Elderly	− 0.42 [− 0.75, − 0.09]	0.032	− 0.26 [− 0.57, 0.04]	0.058
IL-1β
Young adults	Reference	NA	Reference	NA	0.053
Middle-aged adults	− 0.06 [− 0.20, 0.09]	0.461	− 0.01 [− 0.16, 0.14]	0.854
Elderly	− 0.00 [− 0.15, 0.15]	0.957	0.07 [− 0.09, 0.22]	0.392
TNF-α
Young adults	Reference	NA	Reference	NA	0.009
Middle-aged adults	− 0.04 [− 0.17, 0.08]	0.522	− 0.02 [− 0.15, 0.11]	0.671
Elderly	0.05 [− 0.08, 0.18]	0.434	0.08 [− 0.06, 0.22]	0.248
INF-γ
Young adults	Reference	NA	Reference	NA	0.031
Middle-aged adults	− 0.16 [− 0.45, 0.12]	0.262	− 0.11 [− 0.39, 0.18]	0.524
Elderly	− 0.35 [− 0.65, − 0.06]	0.017	− 0.24 [− 0.55, 0.06]	0.127
MMP-8
Young adults	Reference	NA	Reference	NA	0.044
Middle-aged adults	− 0.23 [− 0.63, 0.18]	0.271	− 0.19 [− 0.60, 0.21]	0.356
Elderly	− 0.03 [− 0.45, 0.38]	0.869	− 0.01 [− 0.40, 0.41]	0.959
TIMP-1
Young adults	Reference	NA	Reference	NA	0.111
Middle-aged adults	− 0.08 [− 0.34, 0.18]	0.537	− 0.03 [− 0.29, 0.21]	0.776
Elderly	− 0.13 [− 0.40, 0.13]	0.328	0.00 [− 0.26, 0.26]	0.996

Data is presented as beta-coefficient (β) with a 95% confidence interval [CI]. All biomarkers are log-transformed. ^*Adjusted for ethnic background, gender, admission type, readmission, direct hit for ARDS, Charlson Comorbidity Index, APACHE-IV score adjusted for age, immunodeficiency, tidal volume per predicted body weight, and positive end-expiratory pressure. A p value < 0.05 was considered as statistically significant. IL interleukin, TNF-α tumor necrosis factor alpha, INF-γ, interferon gamma, MMP-8 matrix metalloproteinase-8, and TIMP-1 metallopeptidase inhibitor-1. Goodness of fit, adjusted R². NA not applicable

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