Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Intensive Care Medicine Experimental

Table 5 Association between age and coagulation marker levels in ARDS patients (mediation step 3)

	Coefficient [95% CI]	p value	Coefficient [95% CI]^*	p value	Adjusted R²
Platelet factor 4
Young adults	Reference	NA	Reference	NA	0.138
Middle-aged adults	0.26 [− 0.24, 0.76]	0.313	0.26 [− 0.21, 0.74]	0.262
Elderly	0.59 [0.05, 1.08]	0.033	0.36 [− 0.14, 0.87]	0.129
d-Dimer
Young adults	Reference	NA	Reference	NA	0.031
Middle-aged adults	− 0.02 [− 0.22, 0.19]	0.857	− 0.01 [− 0.22, 0.20]	0.942
Elderly	0.02 [− 0.19, 0.23]	0.829	0.03 [− 0.19, 0.24]	0.870
Tissue plasminogen activator
Young adults	Reference	NA	Reference	NA	0.063
Middle-aged adults	0.05 [− 0.15, 0.26]	0.520	0.08 [− 0.13, 0.28]	0.459
Elderly	0.18 [− 0.04, 1.39]	0.103	0.24 [0.02, 0.45]	0.032
PAI-1
Young adults	Reference	NA	Reference	NA	0.141
Middle-aged adults	− 0.31 [− 0.64, 0.03]	0.072	− 0.21 [− 0.54, 0.10]	0.141
Elderly	− 0.33 [− 0.68, 0.01]	0.054	− 0.21 [− 0.54, 0.12]	0.177
Protein C
Young adults	Reference	NA	Reference	NA	0.035
Middle-aged adults	− 0.00 [− 0.09, 0.09]	0.989	0.00 [− 0.09, 0.09]	0.973
Elderly	− 0.05 [− 0.15, 0.04]	0.265	− 0.07 [− 0.17, 0.03]	0.204
Anti-thrombin
Young adults	Reference	NA	Reference	NA	0.066
Middle-aged adults	− 0.00 [− 0.13, 0.12]	0.992	0.01 [− 0.12, 0.13]	0.850
Elderly	− 0.04 [− 0.82, 0.09]	0.564	− 0.03 [− 0.16, 0.10]	0.295

Data is presented as beta-coefficient (β) with a 95% confidence interval [CI]. All biomarkers are log-transformed. ^*Adjusted for ethnic background, gender, admission type, readmission, direct hit for ARDS, Charlson Comorbidity Index, APACHE-IV score adjusted for age, immunodeficiency, tidal volume per predicted body weight, positive end-expiratory pressure. A p value < 0.05 was considered as statistically significant. PAI-1, plasminogen activator inhibitor-1. Goodness of fit, adjusted R². NA not applicable