Fig. 1
From: Methane and Inflammation - A Review (Fight Fire with Fire)
Documented CH4-mediated mechanisms in experimental models of sepsis, endotoxemia and systemic inflammation. ATF4, activating transcription factor 4; Bax. Bcl-2-associated X protein; Bcl-2, B cell lymphoma 2; CHOP, C/EBP homologous protein; CLP, cecal ligation and puncture; CNS, central nervous system; CytC, cytochrome C; ENS, enteric nervous system; ER, endoplasmic reticulum; GRP78, glucose-regulated protein 78; GSK-3β, glycogen synthase kinase 3 beta; GSH, glutathione; GSSG, glutathione disulphide; HO-1, heme oxygenase 1; IL-1β, interleukin 1 beta; IL-6, IL-10, interleukin 6 and interleukin 10, respectively; I/R, ischemia/reperfusion; LPS, lipopolysaccharide; MAPKs, mitogen-activated protein kinase; MPO, myeloperoxidase; NF-κB, nuclear factor-κB; NLRP3, NOD-like receptor protein 3; PARP, poly (ADP-ribose) polymerase; PPAR-γ, peroxisome proliferator-activated receptor gamma; ROS, reactive oxygen species; SOD, superoxide dismutase; TLR4, Toll-like receptor 4; TNF-α, tumour necrosis factor alpha; XOR, xanthine oxidoreductase