Table 1 Haemodynamic-, MRI-, and blood-gas measurements. Values are expressed as medians with 95% confidence intervals (lower limit, higher limit). Groups are compared using Wilcoxon- Mann-Whitney U test. MRI magnetic resonance imaging, HR heart rate, MAP mean arterial pressure, MPAP mean pulmonary artery pressure, Wedge pulmonary wedge pressure, CVP central venous pressure, LVPmax maximum left ventricle (LV) pressure, dP/dtmax maximum LV pressure first time derivate, dP/dtmin minimum LV pressure first time derivate, LV ESP left ventricular end-systolic pressure, LV EDP left ventricular end-diastolic pressure, COphase cardiac output by cardiac MRI phase-contrast technique, LV EDV left ventricular end-diastolic volume, LV ESV left ventricular end-systolic volume, Wall thickening septum and Wall thickening lat mid-left ventricular radial wall thickening in septum and lateral wall, MAPSE mitral annular plane systolic excursion , LV EF left ventricular ejection fraction. SvO2 mixed venous oxygen saturation, ASAT aspartate transaminase, cTnT cardiac troponin T, TTC triphenyl tetrazolium chloride tissue-staining, LV left ventricle
Variable | Esmolol-group | Control group | P value Difference between groups post-arrest | ||
|---|---|---|---|---|---|
Baseline | Post-arrest | Baseline | Post-arrest | ||
(n = 10) | (n = 7) | (n = 10) | (n = 5) | ||
Haemodynamic variables | |||||
HR (beats/min) | 78 (69, 89) | 137 (95, 180) | 70 (66, 88) | 114 (90, 142) | 0.3 |
MAP (mmHg) | 96 (78, 112) | 75 (62, 88) | 92 (80, 103) | 79 (60, 84) | 0.9 |
MPAP (mmHg) | 22 (18, 25) | 21 (15, 28 | 21 (16, 25) | 24 (17, 30) | 0.6 |
Wedge (mmHg) | 14 (11, 17) | 13 (11, 23) | 13 (10, 24) | 20 (4, 23) | 0.3 |
CVP (mmHg) | 8 (6, 12) | 7 (4, 11) | 9 (8, 12) | 9 (7, 12) | 0.4 |
LVPmax (mmHg) | 106 (93, 120) | 89 (72, 105) | 110 (95, 117) | 90 (71, 98) | 1.0 |
LV ESP (mmHg) | 62 (53, 80) | 52 (41, 58) | 65 (53, 75) | 57 (41, 62) | 0.2 |
LV EDP (mmHg) | 16 (11, 19) | 16 (6, 24) | 16 (14, 21) | 19 (15, 28) | 0.2 |
LV dp/dtmax (mmHg/s) | 1771 (1248, 2448) | 1916 (1322, 3691) | 1677 (1349, 1989) | 1486 (845, 1870) | 0.1 |
LV dp/dtmin (mmHg/s) | − 2339 (− 1756, − 2664) | − 2108 (− 1163, − 2944) | − 2479 (− 1608, − 3624) | − 1586 (− 1375, − 2261) | 0.3 |
MRI measurements | |||||
COphase (l/min) | 4.8 (4.2, 5.6) | 3.5 (3.3, 3.7) | 4.9 (4.6, 5.3) | 3.3 (3.2, 3.9) | 0.7 |
LV SV (ml) | 61 (55, 69) | 27 (18, 39) | 69 (62, 75) | 31 (20, 36) | 0.4 |
LV EDV (ml) | 108 (104, 132) | 87 (72, 91) | 117 (108, 130) | 103 (86, 124) | 0.04 |
LV ESV (ml) | 53 (46, 69) | 62 (53, 70) | 50 (42, 62) | 75 (65, 100) | 0.03 |
LV EF (%) | 50 (41, 66) | 26 (21, 33) | 60 (44, 65) | 25 (19, 29) | 0.5 |
Wall thickening septum (%) | 35 (27, 42) | 21 (1, 37) | 35 (26, 53) | 32 (1, 45) | 1.0 |
Wall thickening lateral (%) | 35 (26, 48) | 26 (12, 32) | 42 (23, 48) | 9 (9, 47) | 0.4 |
MAPSE (mm) | 14.6 (13.4, 14.6) | 6.3 (5.4, 7.5) | 13.4 (13.7, 14.3) | 6.6 (5.8, 8.6) | 1.0 |
Blood gas analysis | |||||
Hb (g/dl) | 8.4 (7.6, 9.8) | 9.0 (7.5, 15.2) | 8.8 (7.8, 9.3) | 9.3 (7.4, 10.0) | 1.0 |
PaO2 (kPa) | 23.4 (20.9, 28.2) | 23.9 (20.1, 34.4 | 24.9 (20.5, 26.2) | 25.3 (23.9, 26.9) | 0.9 |
PaCO2 (kPa) | 4.7 (4.4, 5.4) | 4.6 (2.5, 5.2) | 4.8 (4.4, 4.9) | 4.5 (4.4, 4.8) | 0.9 |
pH | 7.55 (7.52, 7.60) | 7.50 (7.50, 7.80) | 7.55 (7.50, 7.60) | 7.50 (7.50, 7.50) | 0.4 |
Lactate (mmol/l) | 1.0 (0.6, 1.5) | 2.4 (0.7, 3.7 | 0.7 (0.7, 1.0) | 2.3 (2.1, 2.9) | 0.9 |
SvO2 (%) | 58 (37, 76) | 33 (23, 41) | 57 (55, 65) | 38 (35, 45) | 0.04 |
Myocardial injury | |||||
ASAT (U/l) | 31 (21, 46) | 309 (190, 542) | 24 (21, 28) | 354 (136, 1567) | 0.11 |
cTnT (ng/l) | 11 (6, 46) | 3864 (2052, 15727) | 15 (13, 19) | 4014 (1018, 8420) | 0.5 |
Infarct size by MRI (% of LV) | … | 20 (18, 32) | … | 22 (7, 25) | 0.4 |
Infarct size by TTC (% of LV) | … | 20 (16, 30) | … | 25 (9, 34) | 1.0 |