Skip to main content

Table 3 Detailed characteristics of heart failure model

From: Heart failure supported by veno-arterial extracorporeal membrane oxygenation (ECMO): a systematic review of pre-clinical models

Study

Heart failure

Injury model

Procedure description

Complications

Dogs

Sakamoto et al.

Acute

Myocardial infarction

LAD ligation with suture

Kawashima et al.

Acute

Myocardial infarction

LAD ligation (sequential from distal to proximal every 10 min)

Death from VF (3 out of 6)

Yu et al.

Acute

Myocardial infarction

LAD ligation (7 min)

Ox

Segesser et al.

Acute

Pacing

External stimulation to induce VF

Pigs

Møller-Helgestad et al.

Acute

Myocardial infarction

LMCA injection with alcohol microspheres

Death from VF (2 out of 14)

Ostadal et al.

Acute

Myocardial hypoxia

Switch mechanical ventilation to 5 breaths/min, 100 mL VT, and FiO2 21%

Simonsen et al.

Acute

Carbon monoxide poisoning

Carbon monoxide administration

Cardiac arrest (6 out of 12) leading to death (n = 5)

Janak et al.

Acute

Myocardial infarction

LAD and LCx occlusion by balloon inflation (5 min, echo-guided)

Vanhuyse et al.

Acute

Myocardial infarction

LAD ligation (proximal) with tourniquet (60 min)

Esposito et al.

Acute

Myocardial infarction

LCx occlusion (proximal) by balloon inflation (30 mins)

Death from VF (2 out of 10)

Hala et al.

Chronic*

Pacing

Ventricular pacing (200 bpm)

Itoh et al.

Acute

Pacing

Direct 3.5 V alternate current to induce VF

Ostadal et al.

Acute

Myocardial hypoxia

LAD or LCx perfusion with venous blood

VF (2 out of 5)

Brehm et al.

Acute

Drug-induced (Esmolol)

Esmolol bolus bolus at 2 mg/kg into the LA

Kajimoto et al.

Acute

Myocardial infarction

LAD ligation with sutures (10 min)

Death (2 out of 19)

Zhu et al.

Acute

Myocardial infarction

LAD ligation between diagonal branches

Death (2 out of 24)

Bartoli et al.

Acute

Myocardial infarction

LAD ligation (sequential)

Death from arrhythmias (21 out of 47)

Sheep

Sauren et al.

Acute

Myocardial infarction

LCx (or side branches) ligation

“Unstable” (3 out of 7)

Naito et al.

Acute

Drug-induced (Esmolol)

Esmolol bolus at 2 mg/kg into the LA and drip infusion (50 to 500 mg/kg/min)

  1. bpm beats per minute; LAD left anterior descending coronary; LCx left circumflex coronary; LMCA left main coronary artery; VF ventricular fibrillation
  2. *A delay of 4 to 8 weeks was respected in order to obtain clinical signs of heart failure