Comparative effects of flow vs. volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in pigs

Wittenstein, Jakob; Scharffenberg, Martin; Ran, Xi; Keller, Diana; Michler, Pia; Tauer, Sebastian; Theilen, Raphael; Kiss, Thomas; Bluth, Thomas; Koch, Thea; Gama de Abreu, Marcelo; Huhle, Robert

doi:10.1186/s40635-020-00308-0

Intensive Care Medicine Experimental

Table 1 Gas exchange and haemodynamics

From: Comparative effects of flow vs. volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in pigs

Parameter	Therapy				ANOVA (P=)
Group	Mode	20′	40′	60′	Seq	Group	Mode	Time	Mixed
MAP (mmHg)					0.335	0.228	0.329	0.070	0.188
Norm	VCV	80 ± 13	76 ± 13	72 ± 14
Norm	FCV	74 ± 15	73 ± 17	78 ± 28
Hypo	VCV	65 ± 20	65 ± 20	63 ± 22
Hypo	FCV	69 ± 17	67 ± 17	64 ± 17
MPAP (mmHg)					0.292	0.854	0.392	0.946	0.962
Norm	VCV	28 ± 8	26 ± 8	27 ± 7
Norm	FCV	27 ± 8	27 ± 6	27 ± 4
Hypo	VCV	27 ± 7	28 ± 6	28 ± 5
Hypo	FCV	26 ± 7	25 ± 6	25 ± 7
CVP (mmHg)					0.380	0.066	0.368	0.738	0.875
Norm	VCV	4 ± 4	4 ± 4	5 ± 5
Norm	FCV	4 ± 3	3 ± 2	4 ± 2
Hypo	VCV	2 ± 1	2 ± 2	2 ± 2
Hypo	FCV	1 ± 2	2 ± 3	1 ± 2
CO (l/min)					0.744	0.102	0.456	0.540	0.369
Norm	VCV	7.26 ± 1.95	7.19 ± 1.53	7.51 ± 1.21
Norm	FCV	7.22 ± 1.46	7.1 ± 1.42	6.82 ± 1.67
Hypo	VCV	8.59 ± 3.74	8.68 ± 2.75	8.88 ± 2.57
Hypo	FCV	8.95 ± 2.64	8.91 ± 2.37	8.76 ± 2.24
EVLW (mL)					0.868	0.106	0.764	0.146	0.646
Norm	VCV	446 ± 69	455 ± 62	448 ± 61
Norm	FCV	438 ± 41	439 ± 41	438 ± 44
Hypo	VCV	559 ± 179	536 ± 158	499 ± 127
Hypo	FCV	562 ± 203	560 ± 169	530 ± 180
ITBV (mL)					0.008	0.210	0.929	0.879	0.949
Norm	VCV	582 ± 167	566 ± 141	605 ± 173
Norm	FCV	587 ± 222	574 ± 240	560 ± 205
Hypo	VCV	502 ± 90	484 ± 88	487 ± 96
Hypo	FCV	501 ± 128	501 ± 118	540 ± 181
GEDV (mL)					0.008	0.220	0.999	0.974	0.882
Norm	VCV	466 ± 134	450 ± 114	484 ± 138
Norm	FCV	470 ± 177	459 ± 192	449 ± 164
Hypo	VCV	407 ± 70	387 ± 70	390 ± 77
Hypo	FCV	401 ± 103	401 ± 94	432 ± 145
SVR (dyn*s/cm⁵)					0.251	0.156	0.759	0.090	0.870
Norm	VCV	955 ± 294	878 ± 284	805 ± 236
Norm	FCV	1100 ± 436	858 ± 254	940 ± 242
Hypo	VCV	736 ± 433	726 ± 410	682 ± 392
Hypo	FCV	717 ± 306	720 ± 319	700 ± 325
Noradrenalin (mg/h)					0.607	0.031	0.912	0.534	0.790
Norm	VCV	0.28 ± 0.50	0.78 ± 1.39	0.28 ± 0.50
Norm	FCV	0.23 ± 0.39	0.27 ± 0.48	0.28 ± 0.48
Hypo	VCV	1.94 ± 2.19	2.04 ± 2.22	2.25 ± 2.59		0.054
Hypo	FCV	2.12 ± 2.15	2.18 ± 2.28	2.19 ± 2.55		0.022
Hb (mmol/L)					0.483	0.302	0.212	0.678	0.695
Norm	VCV	5.81 ± 0.91	5.64 ± 0.95	5.75 ± 1
Norm	FCV	5.92 ± 1.05	5.78 ± 1.07	5.69 ± 0.85
Hypo	VCV	5.19 ± 0.97	5.11 ± 0.98	5.14 ± 0.91
Hypo	FCV	5.46 ± 0.95	5.45 ± 0.94	5.44 ± 0.87
Shunt (%)					0.944	0.103	0.097	0.050	0.114
Norm	VCV	32.8 ± 11.1	29.8 ± 8.9	29.9 ± 10.2
Norm	FCV	32.5 ± 8.2	32.2 ± 7.7	30.8 ± 8.2
Hypo	VCV	41.7 ± 11.3	40.2 ± 11.6	38.3 ± 10.4
Hypo	FCV	37 ± 9.8	37.7 ± 10.5	39.6 ± 12.1

Values in mean ± standard deviation; Statistical P values according to linear mixed-effects repeated measures ANOVA with with-in subject factors: mode of ventilation (volume or flow-controlled ventilation) and time of therapy in minutes; and between subject factors group of therapy (normovolaemia or hypovolaemia) and randomisation sequence (volume or flow-controlled ventilation first). Significance was accepted for P < 0.05. Statistical analysis was performed in R statistical programming language and the package lme4
FCV flow-controlled ventilation, VCV volume-controlled ventilation, MAP mean arterial pressure, MPAP mean pulmonary arterial pressure, CVP central venous pressure, CO cardiac output, EVLW extravascular lung water, ITBV intrathoracic blood volume, GEDV global end-diastolic volume, SVR systemic vascular resistance, Hb haemoglobin, Shunt intrapulmonary shunt

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