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Table 3 Cardiac work in RV and LV during CS and mechanical support

From: Unloading using Impella CP during profound cardiogenic shock caused by left ventricular failure in a large animal model: impact on the right ventricle

 

Baseline, n = 18

Shock, n = 18

Impella CP + minimally required NE, n = 18

p value

RV SW, mmHg × mL, median (Q1, Q3)

1060 (874, 1287)

333 (263, 530)

830 (717, 1121)

Base vs shock: <0.001

Shock vs Imp: <0.001

RV PE, mmHg × mL, mean (SD)

1.242 (375)

1.662 (529)

1.835 (612)

Base vs shock: 0.001

Shock vs Imp: 0.34

RV PVA × HR*103, mmHg/min, mean (SD)

177 (40)

155 (50)

215 (44)

Base vs shock: 0.171

Shock vs Imp<0.001

LV SW, mmHg × mL, mean (SD)

4351 (4009, 5367)

845 (587, 1421)

1057 (595 1725)

Base vs shock: <0.001

Shock vs Imp: 1.00

LV PE, mmHg × mL, mean (SD)

7986 (1007, 10575)

6495 (5460, 8060)

4714 (3752, 5964)

Base vs shock: 0.004

Shock vs Imp: 0.008

LV PVA × HR*103, mmHg/min, mean (SD)

751 (182)

497 (164)

399 (173)

Base vs shock: <0.001

Shock vs Imp: 0.15

RV/LV PVA × HR ratio, median (Q1, Q3)

0.24 (0.22, 0.28)

0.30 (0.26, 0.38)

0.53 (0.41, 0.76)

Base vs shock: 1.00

Shock vs Imp: 0.001

RV/LV ratio of SW, median (Q1, Q3)

0.23 (0.20, 0.28)

0.44 (0.31, 0.63)

0.82 (0.52, 1.60)

Base vs shock: 0.06

Shock vs Imp: 0.08

  1. NE norepinephrine, RV right ventricle, LV left ventricle, SW stroke work, PE potential energy, PVA pressure-volume area, HR heart rate