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Table 5 Pressure-volume relationship and cardiac work in RV and LV with increased dose of norepinephrine

From: Unloading using Impella CP during profound cardiogenic shock caused by left ventricular failure in a large animal model: impact on the right ventricle

 

Impella CP+minimally required NE, n = 8

Impella CP+moderate NE, n = 8

p value

Pressure-volume relationship

RV EDV, mL, mean (SD)

186 (30)

151 (18)

0.03

RV ESP, mmHg, median (Q1, Q3)

28 (27, 32)

37 (34, 41)

0.03

RV EDP, mmHg, mean (SD)

13 (2)

11 (3)

0.01

RV Ees, mmHg/mL, median (Q1, Q3)

0.22 (0.18, 0.35)

0.42 (0.35, 0.49)

0.03

RV Ea, mmHg/mL, median (Q1, Q3)

0.52 (0.42, 0.54)

0.67 (0.59, 0.81)

0.09

RV Ea/Ees ratio, median (Q1, Q3)

2.1 (1.7, 2.7)

1.5 (1.3, 2.2)

0.12

LV EDV, mL, mean (SD)

171 (42)

168 (42)

0.90

LV ESP, mmHg, median (Q1, Q3)

60 (57, 64)

85 (84, 88)

0.02

LV EDP, mmHg, mean (SD)

16 (5)

16 (5)

0.77

RV/LV EDV ratio, median (Q1, Q3)

1.14 (0.85, 1.34)

0.87 (0,72, 1.19)

0.12

RV/LV EDP ratio, median (Q1, Q3)

0.91 (0.69, 1.08)

0.73 (0.54, 0.96)

0.11

LV Ees, mmHg/mL, median (Q1, Q3)

0.50 (0.40, 0.62)

0.78 (0.59, 0.87)

0.04

LV Ea, mmHg/mL, median (Q1, Q3)

2.05 (1.49, 3.42)

2.49 (1.84, 3.14)

0.48

LV Ea/Ees, median (Q1, Q3)

4.3 (3.8, 6.2)

3.1 (2.6, 4.7)

0.12

Cardiac work

RV SW, mmHg × mL, median (Q1, Q3)

818 (751, 1.065)

1.231 (1.142, 1.335)

0.01

RV PE, mmHg × mL, mean (SD)

1.787 (291)

1.707 (469)

0.63

RV PVA × HR*103, mmHg/min, mean (SD)

205 (27)

299 (77)

0.003

LV SW mmHg × mL, median (Q1, Q3)

858 (555, 1.392)

2.101 (1.024, 2.613)

0.04

LV PE mmHg × mL, mean (SD)

3.810 (1.105)

4.833 (1.695)

0.28

LV PVA × HR*103, mean (SD) mmHg/min

363 (89)

687 (235)

0.007

  1. NE norepinephrine, RV right ventricle, LV left ventricle, EDV end-diastolic volume, ESP end-systolic pressure, EDP end-diastolic pressure, Ees end-systolic pressure-volume relationship, Ea arterial elastance, SW stroke work, PE potential energy, PVA pressure-volume area, HR heart rate