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Table 1 Characteristics at baseline and after trauma but prior to start of resuscitation

From: Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

  Control ADAMTS-13
  Baseline Hemorrhagic shock Baseline Hemorrhagic shock
Clinical parameters
n 7 8
 Weight (g) 373.6 (13.4) 360.6 (24.8)
 Temperature (°C) 36.6 (0.8) 36.9 (0.5) 36.8 (0.6) 36.8 (0.9)
Chemical lab
 Hemoglobin level (g/dL) 14.0 (1.2) 11.1 (1.0)† 15.7 (0.5)* 11.7 (0.6)†
 Creatinine (μmol/L) 25.4 (3.5) ND 23.4 (2.9) ND
 ASAT (U/L) 63.9 (4.0) ND 63.3 (9.5) ND
 ALAT (U/L) 54.6 (4.1) ND 53.1 (6.9) ND
 LDH (U/L) 153.7 (89.0) ND 129.6 (49.1) ND
 vWF antigen (% of poolplasma) 72 (29–84) ND 94 (86–101)* ND
Blood gas
 pH 7.44 (0.07) 7.32 (0.11) 7.38 (0.04) 7.33 (0.07)
 pCO2 (mmHg) 35.4 (5.3) 28.2 (8.7)† 41.0 (7.4) 34.6 (6.6)
 HCO3 (mEq/L) 23.3 (1.9) 15.1 (6.5)† 23.6 (2.5) 17.5 (1.8)†
 BD (mmol/L) − 0.5 (2.6) − 9.9 (7.5)† − 1.4 (1.6) − 7.6 (2.1)†
 Lactate (mmol/L) 0.9 (0.3) 5.2 (4.7) 0.9 (0.3) 3.7 (1.2)†
Hemodynamics
 MAP (mmHg) 133 (15) 43 (11)† 149 (9) 44 (3)†
 Heartrate (bpm) 282 (32) 265 (54) 270 (18) 252 (31)
ROTEM
 Clotting time (s) 49.6 (5.5) 49.3 (3.1) 49.6 (4.6) 43.1 (5.0)†
 Mean clot firmness (mm) 69.7 (2.9) 64.0 (4.7)† 69.9 (1.5) 68.9 (2.1)
 α-angle (°) 81.7 (1.1) 80.1 (1.8)† 82.5 (0.5) 81.9 (0.6)†
 Maximum lysis (%) 5.9 (3.1) 0.9 (0.7)† 2.3 (2.3)* 0.9 (1.5)†
  1. Values are presented as mean and standard deviation (SD) or median and interquartile range (IQR)
  2. BD base deficit, MAP mean arterial pressure, ND not done, NA not applicable
  3. *Significantly different from control, p < 0.05
  4. †Significantly different from baseline, p < 0.05