Table 1 Characteristics at baseline and after trauma but prior to start of resuscitation
| Â | Control | ADAMTS-13 | ||
|---|---|---|---|---|
| Â | Baseline | Hemorrhagic shock | Baseline | Hemorrhagic shock |
Clinical parameters | ||||
 n | 7 | 8 | ||
 Weight (g) | 373.6 (13.4) | 360.6 (24.8) | ||
 Temperature (°C) | 36.6 (0.8) | 36.9 (0.5) | 36.8 (0.6) | 36.8 (0.9) |
Chemical lab | ||||
 Hemoglobin level (g/dL) | 14.0 (1.2) | 11.1 (1.0)†| 15.7 (0.5)* | 11.7 (0.6)†|
 Creatinine (μmol/L) | 25.4 (3.5) | ND | 23.4 (2.9) | ND |
 ASAT (U/L) | 63.9 (4.0) | ND | 63.3 (9.5) | ND |
 ALAT (U/L) | 54.6 (4.1) | ND | 53.1 (6.9) | ND |
 LDH (U/L) | 153.7 (89.0) | ND | 129.6 (49.1) | ND |
 vWF antigen (% of poolplasma) | 72 (29–84) | ND | 94 (86–101)* | ND |
Blood gas | ||||
 pH | 7.44 (0.07) | 7.32 (0.11) | 7.38 (0.04) | 7.33 (0.07) |
 pCO2 (mmHg) | 35.4 (5.3) | 28.2 (8.7)†| 41.0 (7.4) | 34.6 (6.6) |
 HCO3− (mEq/L) | 23.3 (1.9) | 15.1 (6.5)†| 23.6 (2.5) | 17.5 (1.8)†|
 BD (mmol/L) | − 0.5 (2.6) | − 9.9 (7.5)†| − 1.4 (1.6) | − 7.6 (2.1)†|
 Lactate (mmol/L) | 0.9 (0.3) | 5.2 (4.7) | 0.9 (0.3) | 3.7 (1.2)†|
Hemodynamics | ||||
 MAP (mmHg) | 133 (15) | 43 (11)†| 149 (9) | 44 (3)†|
 Heartrate (bpm) | 282 (32) | 265 (54) | 270 (18) | 252 (31) |
ROTEM | ||||
 Clotting time (s) | 49.6 (5.5) | 49.3 (3.1) | 49.6 (4.6) | 43.1 (5.0)†|
 Mean clot firmness (mm) | 69.7 (2.9) | 64.0 (4.7)†| 69.9 (1.5) | 68.9 (2.1) |
 α-angle (°) | 81.7 (1.1) | 80.1 (1.8)†| 82.5 (0.5) | 81.9 (0.6)†|
 Maximum lysis (%) | 5.9 (3.1) | 0.9 (0.7)†| 2.3 (2.3)* | 0.9 (1.5)†|