| |
Control
|
ADAMTS-13
|
|---|
| |
Baseline
|
Hemorrhagic shock
|
Baseline
|
Hemorrhagic shock
|
|---|
|
Clinical parameters
|
|
n
|
7
|
8
|
|
Weight (g)
|
373.6 (13.4)
|
360.6 (24.8)
|
|
Temperature (°C)
|
36.6 (0.8)
|
36.9 (0.5)
|
36.8 (0.6)
|
36.8 (0.9)
|
|
Chemical lab
|
|
Hemoglobin level (g/dL)
|
14.0 (1.2)
|
11.1 (1.0)†
|
15.7 (0.5)*
|
11.7 (0.6)†
|
|
Creatinine (μmol/L)
|
25.4 (3.5)
|
ND
|
23.4 (2.9)
|
ND
|
|
ASAT (U/L)
|
63.9 (4.0)
|
ND
|
63.3 (9.5)
|
ND
|
|
ALAT (U/L)
|
54.6 (4.1)
|
ND
|
53.1 (6.9)
|
ND
|
|
LDH (U/L)
|
153.7 (89.0)
|
ND
|
129.6 (49.1)
|
ND
|
|
vWF antigen (% of poolplasma)
|
72 (29–84)
|
ND
|
94 (86–101)*
|
ND
|
|
Blood gas
|
|
pH
|
7.44 (0.07)
|
7.32 (0.11)
|
7.38 (0.04)
|
7.33 (0.07)
|
|
pCO2 (mmHg)
|
35.4 (5.3)
|
28.2 (8.7)†
|
41.0 (7.4)
|
34.6 (6.6)
|
|
HCO3− (mEq/L)
|
23.3 (1.9)
|
15.1 (6.5)†
|
23.6 (2.5)
|
17.5 (1.8)†
|
|
BD (mmol/L)
|
− 0.5 (2.6)
|
− 9.9 (7.5)†
|
− 1.4 (1.6)
|
− 7.6 (2.1)†
|
|
Lactate (mmol/L)
|
0.9 (0.3)
|
5.2 (4.7)
|
0.9 (0.3)
|
3.7 (1.2)†
|
|
Hemodynamics
|
|
MAP (mmHg)
|
133 (15)
|
43 (11)†
|
149 (9)
|
44 (3)†
|
|
Heartrate (bpm)
|
282 (32)
|
265 (54)
|
270 (18)
|
252 (31)
|
|
ROTEM
|
|
Clotting time (s)
|
49.6 (5.5)
|
49.3 (3.1)
|
49.6 (4.6)
|
43.1 (5.0)†
|
|
Mean clot firmness (mm)
|
69.7 (2.9)
|
64.0 (4.7)†
|
69.9 (1.5)
|
68.9 (2.1)
|
|
α-angle (°)
|
81.7 (1.1)
|
80.1 (1.8)†
|
82.5 (0.5)
|
81.9 (0.6)†
|
|
Maximum lysis (%)
|
5.9 (3.1)
|
0.9 (0.7)†
|
2.3 (2.3)*
|
0.9 (1.5)†
|
- Values are presented as mean and standard deviation (SD) or median and interquartile range (IQR)
- BD base deficit, MAP mean arterial pressure, ND not done, NA not applicable
- *Significantly different from control, p < 0.05
- †Significantly different from baseline, p < 0.05
