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Intensive Care Medicine Experimental
Fig. 5 | Intensive Care Medicine Experimental

Fig. 5

From: Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation

Fig. 5

Correlation network generated from transcriptional differences in circulating leukocytes derived from COVID19 + and COVID19− critically ill patients. Each node represents a unique gene set and the edges represent the coefficient of similarity between gene sets above a defined threshold. Markov Cluster Algorithm (MCL) clustering analyses revealed groups of gene transcript nodes, where platelet activation, neurotrophin signalling, toll-like receptor signalling cascades, and sumoylation/ubiquitination pathways were identified as the top four nodes. Red indicates positive enrichment of gene transcripts and blue indicates negative enrichment of gene transcripts.

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