A novel experimental porcine model to assess the impact of differential pulmonary blood flow on ischemia–reperfusion injury after unilateral lung transplantation

Intensive Care Medicine Experimental

Table 2 Cytokine measurements in plasma of low- vs high-flow group

Cytokines	LLOQ (pg/ml)	LF	HF	p-value
IFN-alpha	0.6	0.5 (0.3–3.6)	0.9 (0.6–1.4)	0.33
IFN-gamma	4.5	5.4 (4.6–12.9)	13.9 (10.4–46.9)	0.10
IL-1beta	3.2	11.3 (5–299.1)	17.4 (8.3–32.9)	0.59
IL-10	18	56 (24.7–535.5)	73.5 (55.2 -89.2)	0.70
IL-12p40	30	510.1 (221.6–720.3)	265.5 (214.6–901.6)	0.82
IL-4	1.5	2.5 (0.7–5.4)	1.9 (1.8–2.5)	> 0.99
IL-6	5.9	73.5 (36.9–745)	150.4 (102.1–260.2)	0.18
IL-8	16	43.1 (22.1–1172)	30.4 (23.2–35.4)	0.67
TNF-alpha	6.5	101.7 (3.2–1139)	3.2 (3.2–85.7)	0.32

Cytokine measurements for the cytokines: interferon-α (IFN-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), interleukin-10 (IL-10), interleukin-12p40 (IL-12p40), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were not significant in the low vs. high-flow group. Data are expressed as median (25%–75% interquartile range); and Mann–Whitney test was used for comparing the two groups; LLOQ lower limit of quantification, pg/ml, picogram/milliliter, LF low flow, HF high flow