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Intensive Care Medicine Experimental

Table 2 Uni- and multivariate analysis of variables associated with the bias between methods

From: Validation of a novel system to assess end-expiratory lung volume and alveolar recruitment in an ARDS model

Variables

Univariate coefficient

Univariate p value

Multivariate coefficient

Multivariate p value

PEEP (per 1 cm H2O increase)

− 7.2 ± 1.5

 < 0.0001

–

–

VT (per 10 ml increase)

3.1 ± 1.4

 < 0.05

–

–

PEEPTOT (per 1 cm H2O increase)

− 7.0 ± 1.4

 < 0.0001

–

–

PPLAT (per 1 cm H2O increase)

− 2.1 ± 1.9

 < 0.05

–

–

ΔP (per 1 cm H2O increase)

4.5 ± 1.7

 < 0.01

–

–

RR (per 1 cycle.min−1 increase)

− 3.5 ± 1.5

 < 0.05

–

–

CO (per 1 L.min−1 increase)

36.7 ± 9.8

 < 0.05

–

–

Overinf. cpt at expiration (per 1 mL increase)

− 8.5 ± 1.7

 < 0.0001

− 8.7 ± 1.8

 < 0.0001

Overinf. cpt at inspiration (per 1 mL increase)

− 3.8 ± 1.1

 < 0.01

–

–

Non-inf. cpt at expiration (per 1 mL increase)

0.12 ± 0.05

 < 0.05

–

–

  1. Bias between methods was computed as EELVMBNW minus EELVCT. PEEP and ΔP were not included in the multivariate model for collinearity with PEEPTOT
  2. CO cardiac output; ∆P driving pressure EELVCT end-expiratory lung volume assessed with computed tomography; EELVMBNW end-expiratory lung volume assessed with the multiple breaths N2 washin–washout technique; non-inf. cpt non-inflated compartment on CT; overinf. cpt. overinflated compartment on CT; PEEP positive end-expiratory pressure; PEEPTOT total positive end-expiratory pressure; PPLAT plateau pressure; RR respiratory rate; VT tidal volume
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