Table 1 Effect of PEEP on expiratory cardio-respiratory variables
IAP, cmH2O | BL | 27 | 27 | 27 | 27 | 27 | P, PEEP |
|---|---|---|---|---|---|---|---|
PEEP, cmH2O (% of IAP) | 5 | 5 (19) | 12 (44) | 17 (63) | 22 (81) | 27 (100) | |
Healthy lungs | |||||||
P/F ratio, mmHg | 542 (539,547) | 502 (499,504) | 532 (492,554) | 512 (512,549) | 513 (502,522) | 515 (514,546) | 0.37 |
Paw, insp, cmH2O | 17 (16,17) | 31 (31,33)# | 37 (36,38) | 41 (38,41) | 43 (42,44) | 51 (51,52) | < 0.01 |
Pes, exp, cmH2O | 10 (6,11) | 12 (9,12) | 17 (14,18) | 21 (19,21) | 24 (23,25) | 27 (26,27) | < 0.01 |
Pes, insp, cmH2O | 13 (11,14) | 29 (28,30)# | 34 (31,34) | 36 (33,36) | 38 (36,38) | 43(41,43) | < 0.01 |
Ers, cmH2O/L | 39 (39,42) | 103 (99,103)# | 94 (93,99) | 85 (84,86) | 81 (75,82) | 92 (87,100) | < 0.01 * |
EW, cmH2O/L | 16 (14,18) | 67 (64,73)# | 66 (59,71) | 53 (53,62) | 55 (53,56) | 60 (60,61) | 0.71 |
EL, cmH2O/L | 26 (21,28) | 35 (30,41)# | 35 (27,35) | 30 (25,32) | 27 (25,27) | 31 (27,33) | 0.02 |
C.O., L/min | 4.2 (4.1,4.5) | 4.4 (4.0,4.7) | 3.9 (3.6,3.9) | 3.2 (3.2,3.4) | 2.9 (2.8,2.9) | 2.8 (2.7,2.9) | < 0.01 |
Total lung volume, L | 1.2 (1.1,1.2) | 0.8 (0.7,0.8)# | 0.9 (0.9,1.0) | 1.0 (1.0,1.0) | 1.1 (1.1,1.2) | 1.3 (1.2,1.3) | < 0.01 |
Lung gas volume, mL | 721 (698,791) | 378 (370,418)# | 511 (501,561) | 620 (611,649) | 761 (743,788) | 903 (856,908) | < 0.01 |
Lung tissue mass, g | 393 (356,412) | 338 (316,354) | 355 (334,358) | 352 (329,361) | 353 (338,369) | 351 (322,367) | 0.60 |
Overdistended, % | 2 (2,2) | 1 (1,2) | 2 (1,3) | 2 (2,4) | 4 (3,5) | 5 (4,7) | < 0.01 |
Normally aerated, % | 82 (79,85) | 56 (50,65)# | 68 (63,74) | 75 (70,80) | 79 (76,83) | 82 (82,86) | < 0.01 |
Poorly aerated, % | 14 (11,16) | 32 (27,36)# | 23 (20,38) | 18 (15,22) | 14 (10,16) | 9 (8,11) | < 0.01 |
Atelectatic, % | 2 (1,4) | 10 (7,15) | 5 (4,7) | 3 (2,4) | 3 (2,3) | 2 (1,2) | < 0.01 |
Injured lungs | |||||||
P/F ratio, mmHg | 153 (146,232)‡ | 175 (163,201)‡ | 235 (187,272) | 244 (178,326) | 285 (240,409) | 243 (165,312) | 0.04 * |
Paw, insp, cmH2O | 23 (23,24)‡ | 38 (31,40)#‡ | 40 (40,41) | 44 (42,44) | 47 (46,47) | 57 (54,57) | < 0.01 * |
Pes, exp, cmH2O | 10 (9,19) | 30 (30,32) | 34 (32,38) | 38 (34,39) | 40 (37,41) | 44 (39,45) | < 0.01 * |
Pes, insp, cmH2O | 17 (14,23) | 16 (13,18)# | 20 (18,22) | 23 (23,24) | 26 (26,28) | 29 (29,30) | < 0.01 |
Ers, cmH2O/L | 73 (62,75)‡ | 115 (101,148)#‡ | 109 (102,116) | 101 (92,103) | 89 (85,95) | 105 (104,106) | < 0.01 * |
EW, cmH2O/L | 19 (17,19) | 62 (56,63)# | 61 (50,73) | 54 (46,59) | 53 (52,53) | 57 (50,62) | 0.40 |
EL, cmH2O/L | 50 (4,53)‡ | 53 (49,74)‡ | 42 (40,50) | 38 (36,46) | 35 (34,38) | 48 (45,52) | < 0.01 * |
C.O., L/min | 4.0 (3.4,4.8) | 4.2 (4.0,4.5) | 3.3 (3.0,3.7) | 3.2 (2.8,3.2) | 3.1 (3.0,3.6) | 3.3 (2.5,3.9) | 0.01 |
Total lung volume, L | 1.0 (1.0,1.0) | 1.0 (0.9,1.1) | 1.2 (1.0,1.2) | 1.3 (1.0,1.4) | 1.5 (1.2,1.5) | 1.7 (1.3,1.7) | < 0.01 |
Lung gas volume, mL | 522 (519,596)‡ | 428 (381,449) | 569 (482,609) | 744 (570,762) | 885 (732,933) | 1024 (827,1104) | < 0.01 |
Lung tissue mass, g | 397 (372,399) | 446 (361,454) | 489 (381,521) | 526 (392,546) | 546 (424,557) | 548 (429,560) | 0.01 |
Overdistended, % | 2 (2,3) | 2 (1,2) | 2 (2,3) | 3 (2,3) | 3 (3,3) | 5 (4,6) | < 0.01 |
Normally aerated, % | 61 (57,66)‡ | 44 (35,51) | 55 (45,59) | 60 (53,65) | 63 (58,70) | 69 (65,74) | < 0.01 |
Poorly aerated, % | 24 (22,26) | 26 (22,31) | 25 (22,29) | 24 (21,29) | 24 (18,27) | 19 (15,25) | < 0.01 |
Atelectatic, % | 11 (8,13) | 26 (15,35)#‡ | 18 (10,23) | 11 (7,15) | 6 (3,7) | 3 (24) | < 0.01 |