Table 2 Top-ranked metabolites linked with survival ranked by ensemble machine learning-derived summary importance score (defined as those with importance score ≥ 0.5), with corresponding median (interquartile range) normalized levels among septic patients who survived (N = 35) and those who died (N = 25)
From: Machine learning approaches to the human metabolome in sepsis identify metabolic links with survival
Metabolite | Ensemble metabolite importance score | Median (IQR) normalized level among sepsis patients who survived (N = 35) | Median (IQR) normalized level among sepsis patients who died (N = 25) | p value |
|---|---|---|---|---|
3-Hydroxyisobutyrate1 | 0.875 | 252,438.3 (205,768.5–330,512.0) | 447,733.7 (317,285.8–649,937.2) |  < 0.001 |
Glycolithocholate sulfate1 | 0.875 | 25,510.2 (10,242.8–134,807.9) | 79,337.8 (43,853.3–180,873.5) | 0.013 |
Kynurenine | 0.875 | 1,210,710.5 (842,693.3–1,538,991.4) | 2,157,986.3 (1,661,243.8–3,509,181.0) |  < 0.001 |
Glycochenodeoxycholate | 0.75 | 272,981.5 (167,008.1–465,149.2) | 732,421.1 (438,467.2–1,813,588.0) | 0.007 |
Phenylalanine | 0.75 | 32,946,718 (28,021,921–39,246,282) | 43,833,240 (35,133,532–66,127,232) | 0.001 |
Beta-hydroxyisovalerate | 0.625 | 144,346.7 (99,003.9–176,673.7) | 211,728.6 (136,285.5–467,855.3) | 0.006 |
Bilirubin | 0.625 | 49,090.9 (26,390.4–76,850.4) | 114,271.2 (48,093.5–529,768.6) | 0.01 |
Indoleacetate1 | 0.625 | 74,409.6 (51,108.5–84,809.9) | 102,489.8 (81,114.9–136,096.5) | 0.002 |
Taurocholenate sulfate | 0.625 | 102,518.9 (50,764.5–297,900.4) | 468,138.2 (101,984.3–639,836.3) | 0.009 |
3-Methoxytyrosine | 0.5 | 65,256.5 (50,705.4–74,069.8) | 72,094.6 (58,031.8–96,055.7) | 0.024 |
Fucose1 | 0.5 | 148,841.4 (80,563.7–216,589.1) | 260,624.5 (134,398.9–312,514.6) | 0.004 |
Hydroxyisovaleroylcarnitine1 | 0.5 | 127,932.2 (81,047.1–183,819.4) | 237,218.2 (107,023.4–276,240.9) | 0.024 |
Lactate | 0.5 | 91,420,816 (60,458,968–113,868,176) | 147,947,760 (76,580,752–235,829,728) | 0.012 |