Fig. 2

The extracorporeal immune cell therapy is a plasma treatment technology. Plasma is continuously filtered from the patient´s extracorporeal blood circuit and transferred into a closed-loop ‘cell circuit’, where the patient’s plasma is brought into direct contact with therapeutically effective, human-donor immune cells (i.e. the granulocyte concentrate). A Illustrates the procedure of separating plasma from an extracorporeal blood circuit through a plasma filter and feeding the plasma into a second circuit with circulating granulocytes as it has been used in clinical trials using standard granulocyte concentrates B illustrates the streamlined “one way” immune cell perfusion method using purified granulocyte concentrates. Plasma filter CC2 serves as a redundant safety filter