Fig. 2
From: Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases
NO scavenging in hemolysis. The di-oxygenation reaction: during intravascular hemolysis in human disease, oxy-Hb (Fe2+) is able to rapidly bind NO, to form bio-inactive NO3− and met-Hb (Fe3+). The NO scavenging causes consequently vasoconstriction. Exogenous NO can prevent this phenomenon by minimizing the scavenging of endogenous NO. The graph represents the different light absorption wavelengths of oxy-Hb and met-Hb. NO: nitric oxide; Hb: hemoglobin; RBC: red blood cell; NO3−: nitrate