Fig. 4

Albumin kinetics. A Schematic drawing of the volume kinetic model. B Curve-fit in the final model for the dilution-corrected change in plasma albumin concentration versus time. C Increase in the rate constant for capillary leakage of albumin for increasing plasma MR-proANP concentrations. D Predicted versus measured dilution-corrected change in plasma albumin concentration in the final model. E Original data (red points) with the associated 5%, 50%, and 95% quantiles (black lines) and the corresponding quantiles obtained by predictive check based on 1000 simulations using the model parameters in the final model (blue lines). A small difference between observed and predicted quantiles indicates good model performance. F Inhibitory effect of high blood Hgb concentrations on the capillary leakage of albumin.