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Intensive Care Medicine Experimental
Fig. 4 | Intensive Care Medicine Experimental

Fig. 4

From: Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke

Fig. 4

Upper panel. Histology of the heart visualized by hematoxylin–eosin staining in normothermia (NORMO), hypothermia (HYPO), propofol (PRO), dexmedetomidine (DEX) rats. Hyalin necrosis of heart fibers (A–D asterisks, inset). Magnification × 400; inset × 1000. Lower panel. Data are expressed as median (interquartile range quartiles). Mann–Whitney test with Bonferroni multiple comparison between groups was adopted. A p level < 0.0125 was considered statistically significant. Points for severity and extent varied between 0 (no severity/extent) to 4 (maximum severity/extent). The heart injury score was calculated by multiplying the severity and extent of injury (minimum score = 0 and maximum score = 16) and was calculated by the sum of each score for apoptosis, edema, inflammation, and necrosis (minimum score = 0 to maximum score = 64). Magnification × 400; inset × 1000

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