Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis

Intensive Care Medicine Experimental

Table 2 Clinical and infection-related outcomes of study cohorts included in systematic review

First author	ICU LOS mean (sd)	Hospital LOS mean (sd)	28-day mortality	Mortality at longest follow-up; days	Proportion with sepsis (%)	Septic shock mortality (%)	Antibiotic prior to sampling (%)	Antibiotic at any time (%)	Cumulative incidence HAI
Zaborin			3/10(30%)				100	100
Rogers	9.64 (6.40)		1/38(3%)					89
Yeh			3/10 (30%)						25
McDonald	17.3 (13.7)		24/115 (21%)		7.0%		100	100
Howard			2/12 (17%)				0	25
Lankelma	10.9 (12.3)*	45.3(70.8)*	11/34 (32%)	0.74	74%	15%	100	100
Lamarche	13.7 (8.97)	45.3(60.7)	12/34 (35%)		24%	15%
Wan			4/11(27%)	45.5%; various#	100%		100	100
Freedberg			76/301 (25%)						41
Aardema	1.53 (1.09)*	10.5(4.28)*	7/96 (7%)				100	100
Bansal			3/12 25%)		11%
Wijeyesekera			4/60 (7%)		27%		100	100
Xu	15.28 (14.4)		23/98 (23%)	31%; 180
Ravi	23.2(15.0)		4/24 (17%)		100%	17%	42	88
Liu			20/64 (31%)		100%	31%	100	100
Ojima	32.1 (49.5)*		21/71 (30%)	34%; 56	15%	55%	90
Burmeister	15.2 (30.0)*	17.4(13.2)*	8/67(12%)				4		43
Fontaine			15/31 (48%)				55
Chernevskaya			2/18 (13%)
Agudelo-Ochoa	7.86(11.7)				46%	26%
Du			10/25 (40%)		100%	60%		100
Garcia	11.6(14.5)*	38.7(53.6)*	18/62(29%)	29%; 180				100	73
Liu					100%		100	100
Wei	26.6(43.7)		12/49(20%)		8.2%	60%	0
Kuo			7/78(9%)
Prevel			13/57(23%)		35%	35%

Studies included in meta-analysis are highlighted in bold. *Imputed mean (sd) from median with IQR or range using Smith et al. 2016. #censored to hospital discharge. HAI hospital acquired infection