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Intensive Care Medicine Experimental
Fig. 3 | Intensive Care Medicine Experimental

Fig. 3

From: Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients

Fig. 3

PaO2/FiO2 ratio (PFR) vs. Highest Free IL-18 (fIL-18) from symptom day 15 onwards. Highest fIL-18 per patient (n = 97) from symptom day 15 onwards shows an inverse, statistically significant relationship with concurrent PFR (primary outcome), divided into bins as per the Berlin Criteria for acute respiratory distress syndrome (ARDS) severity categories, and extended above 300 mmHg. Multivariate adjusted linear regression shows an increase of 37.7 pg/ml in highest fIL-18 for each decrease in PFR by 100 mmHg (13.3 kPa) (p < 0.03)

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