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Table 3 Evaluation of CO2 clearance of native lung during weaning from V–V ECMO

From: Physiological adaptations during weaning from veno-venous extracorporeal membrane oxygenation

Parameter

Formula

Downsides/specifics

Ventilatory ratio [28]

(VE∙PaCO2)/(PBW∙100∙37.5)

Assumes constant V’CO2NL

Enghoff index

(PaCO2 -PECO2)/PaCO2

Evaluates both shunt and dead space

Ratio of end tidal to partial pressure of carbon dioxide

EtCO2/PaCO2

Evaluates both shunt and dead space [20]

Bohr alveolar dead space

(PACO2 -PECO2)/PACO2

Evaluates pure alveolar dead space but requires analysis of volumetric capnography curve [24]

Ventilatory efficiency

VE/ V’CO2NL

No available data during ECMO

Ventilatory efficiency

∆Peso/ V’CO2NL

Influenced by lung elastance

  1. PBW: predicted body weight
  2. VE: minute ventilation
  3. PECO2: mean expired CO2 partial pressure
  4. PACO2: alveolar CO2 partial pressure