Fig. 1

Effects of either FiO₂s ≤ 0.60 and > O.21 (FiO₂ ≤ 0.60/ > O.21) (upper panel) or FiO₂s ≥ 0.60 (lower panel) vs. FiO₂s = 0.21 (controls) on the odds ratios of survival (95%CIs) (OR) in studies [author (y)] that also administered an infectious or noninfectious inflammatory challenge in animals. Animal type, increased FiO₂ level and duration, and inflammatory challenge route and type employed in studies are also shown. Also noted are the numbers of animals surviving and total numbers of animals in oxygen or control groups. Data from individual regimens of oxygen or challenge that were pooled within studies based on nonsignificant heterogeneity (I² level of significance, p ≥ 0.10) comparing the regimens are shown in Additional file 1: Fig. S2. Overall ORs were pooled across animal type and studies if the significance level for heterogeneity was p ≥ 0.10. While an overall OR could be calculated for FiO₂ ≤ 0.60/ > O.21 (I² = 0%, p = 0.54), this was not possible for FiO₂s ≥ 0.60 due to high heterogeneity (I² = 67%, p = 0.03) comparing rat and mouse. IP intraperitoneal, CLP cecal ligation and puncture, IT intratracheal, IC intracardiac, L. p. Legionella pneumoniae, HCL hydrochloric acid, OA oleic acid