Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Minkove, Samuel; Dhamapurkar, Rhea; Cui, Xizhong; Li, Yan; Sun, Junfeng; Cooper, Diane; Eichacker, Peter Q.; Torabi-Parizi, Parizad

doi:10.1186/s40635-023-00501-x

Intensive Care Medicine Experimental

Table 2 Summary of O₂ only study characteristics

From: Effect of low-to-moderate hyperoxia on lung injury in preclinical animal models: a systematic review and meta-analysis

Author (y)	Country	Animals studied				Oxygen studied		Measures reported
Author (y)	Country	Type (Strain)	Sex	Age	Wgt	FiO₂	Duration	Measures reported
Hackney (1975)	US	Monkey (Squirrel)	M	NR	NR	0.21, 0.60, 0.80	2, 4, 8d	Lung injury^a, lung or systemic immune response parameters^b
Hayatdavoudi (1981)	US	Rat (Charles River – CD)	M	NR	300–350 g	0.21, 0.60, 0.85	7d	Body weights; lung injury; lung or systemic immune response parameters; survival with FiO₂ = 1.0 after prior lower FiO₂ exposure
Rister (1983)	Germany	Guinea pigs	NR	NR	NR	0.21, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80	0, 18, 42, 60, 90 h	Lung injury
Coursin (1987)	US	Rats (SD)	M	NR	160–200 g	0.21, 0.50, 0.65, 0.80	7, 14, 21, 28, 42d	Body weights; lung injury; lung or systemic immune response parameters; Survival with FiO₂ = 1.0 after prior lower FiO₂ exposure
Holm (1987)	US	Rabbits (NZW)	M	NR	1.9–2.2 kg	0.21, 0.60	21d	Lung injury; lung or systemic immune response parameters
Nickerson (1990)	US	Rabbits (NZW)	NR	NR	2.0–3.0 kg	0.21, 0.60	21d	Lung injury
Nylen (1993)	US	Hamsters (Syrian Gold)	M	6weeks	NR	0.21, 0.60	7, 21, 90d	Body weight; lung injury
Van Klaveren (1997)	Belgium, UK	Rats (Wistar)	M	NR	NR	0.21, 0.60, 0.85	7d	Body weight; lung injury; lung or systemic immune response parameters; survival
Belik (2003)	Canada	Rats (SD)	F	NR	250–275 g	0.21, 0.60	14d	Lung injury
Nelin (2003)	US	Rats (SD)	M	NR	250–325 g	0.21, 0.50, 0.90	2.5d	Body weight; lung injury; salicylate conversion to 2,3-DHBA to assess lung hydroxyl radical oxidant production
Hesse (2004)	Germany	Mice (C57BL6/J)	M	12–16 wk	26–27 g	0.21, 0.60, > 0.95	3d	Body weight; lung injury; lung or systemic immune response parameters; body weight; survival
Gan (2011)	US	Rats (SD)	M	NR	275–325 g	0.21, 0.60, 0.85	7d	Body weight; lung injury; lung or systemic immune response parameters
Audi (2012)	US	Rats (SD)	M	NR	300–325 g	0.21, 0.60, 0.95	60–7d 95–2d	Lung injury; lung or systemic immune response parameters
Lagishetty (2014)	US	Mice (C57BL/6 J)	M	9 weeks	NR	0.21, 0.50, 0.75, 1.0	3d	Lung injury; lung or systemic immune response parameters; lung tissue expression of 6 CLOCK proteins (CLOCK, Bmal1, Cry1, Cry2, Per1, Per2)

F female, M male, MAC macrophage, NR not reported, NZW New Zealand White, SD Sprague–Dawley, UC unclear, US United States, UK United Kingdom, Wgt weight, Bmal1—CLOCK circadian locomotor output cycles kaput, 2,3-DHBA dihydroxy benzoic acid, GSH glutathione, HMPAQ Tc labele3d hexamethylpropyleneamine oxide (trapped in the lung by GSH), DEM GSH depleter diethyl maleate, GSH-glutathione GSSG-oxidized glutathione
^aLung injury measures included one or more of the following: arterial oxygen pressure; lung weights, lung wet to dry weight ratios, lung to body weight ratios; bronchoalveolar lavage (BAL) volume, cell, protein or albumin concentrations; alveolar permeability to solute; lung pressure/volume relationships, lung volumes, diffusion capacity; lung histologic changes; pulmonary artery and airway contractile and relaxation function, and/or alveolar macrophage and neutrophil microtubule and microfilament integrity, BAL type-2 cell dysfunction or phospholipid content
^bLung or systemic immune response parameters included one or more of the following: BAL cellularity and polymorphonuclear neutrophil cell numbers, BAL or lung tissue macrophages, BAL or lung tissue lymphocytes; BAL or serum cytokine, nitric oxide, or nitric oxide synthase levels; lung antioxidant activity which included HMPAQ retention with or without DEM based on lung to background ratio, lung or BAL glutathione peroxidase (GPx), glutathione (GSH), oxidized glutathione (GSSG), gamma-glutamyltransferase, non-protein-sulfhydral (NPSH), and/or superoxide dismutase (SOD) levels

Back to article page