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Table 2 Blood gases and blood samples during partial resuscitative endovascular balloon occlusion of the aorta

From: A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury

 

Baseline

Hemorrhage

15 min REBOA

30 min REBOA

45 min REBOA

15 min reperfusion

60 min reperfusion

120 min reperfusion

180 min reperfusion

Arterial pO2 (kPa)

 pREBOAETCO2

12.2 (11.7–12.6)

12.1 (11.5–12.7)

12.9 (11.9–14.0)

13.0 (11.8–14.1)

13.4 (12.2–14.5)

10.3 (9.7–10.8)

11.1 (10.5–11.6)

11.4 (10.7–12.1)

11.6 (11.0–12.3)

 pREBOASBP

11.8 (11.1–12.6)

12.1 (10.9–13.3)

13.5 (12.1–14.8)

14.1 (13.3–14.9)

13.7 (12.4–14.9)

10.8 (9.9–11.8)

10.8 (10.2–11.4)

11.3 (10.4–12.2)

11.6 (10.9–12.3)

Mes. ven. pO2 (kPa)

 pREBOAETCO2

5.5 (5.0–5.9)

4.1 (3.8–4.4)a

4.4 (4.1–4.7)

4.2 (3.9–4.5)

4.6 (4.2–5.0)

6.1 (5.9–6.4)

6.4 (6.0–6.9)

6.5 (6.2–6.9)

5.8 (5.4–6.2)

 pREBOASBP

5.0 (4.5–5.5)

3.6 (3.3–3.9)a

4.2 (3.9–4.4)

4.3 (4.1–4.5)

4.4 (4.1–4.6)

6.5 (6.0–7.0)

6.9 (6.6–7.2)

6.1 (5.8–6.5)

5.7 (5.2–6.1)

VO2 (ml O2 min−1)

 pREBOAETCO2

93 (73–113)

66 (48–85)

54 (43–65)

56 (45–67)

52 (41–63)

84 (68–102)

80 (64–96)

77 (61–93)

72 (56–89)

 pREBOASBP

87 (81–94)

56 (48–64)

52 (45–59)

53 (47–59)

51 (44–58)

87 (78–96)

88 (80–96)

80 (71–90)

75 (63–87)

VCO2 (ml CO2 min−1)

 pREBOAETCO2

108 (98–117)

82 (72–91)

88 (82–93)

86 (79–94)

81 (74–88)

112 (104–119)

101 (94–107)

93 (88–98)

90 (83–96)

 pREBOASBP

102 (93–111)

77 (69–85)

78 (69–86)

79 (71–86)

72 (63–80)

112 (104–120)

104 (97–111)

95 (85–104)

87 (75–99)

DO2 (ml/min)

         

 pREBOAETCO2

669 (577–762)

276 (222–331)

261 (186–335)

279 (195–363)

283 (192–373)

419 (276–562)

635 (517–753)

550 (479–622)

515 (438–590)

 pREBOASBP

560 (448–672)

216 (180–252)

239 (195–283

232 (182–282)

232 (184–281)

305 (240–370)

557 (430–683)

515 (392–637)

436 (266–605)

O2ER

         

 pREBOAETCO2

38 (32–44)

76 (71–81)

64 (55–73)a

60 (51–68)

64 (52–76)

52 (45–59)

38 (33–43)

45 (31–59)

45 (35–54)

 pREBOASBP

38 (32–45)

80 (79–82)

52 (42–62)a

57 (48–67)

55 (44–66)

58 (51–66)

45 (39–50)

45 (41–50)

50 (39–61)

Creatinine (μmol L−1)

 pREBOAETCO2

60 (55–64)

     

87 (76–97)a

 

93 (74–112)a

 pREBOASBP

62 (56–68)

     

99 (91–106)a

 

117 (105–130)a

Troponin (ηg L−1)

 pREBOAETCO2

471 (290–766)

     

2641 (1166–5984)a

 

5366 (1768–5366)a

 pREBOASBP

513 (381–690)

     

7384 (3966–13,747)a

 

20,171 (8748–46,514)a

ALAT (μkat L−1)

 pREBOAETCO2

1.1 (0.9–1.4)

     

1.1 (0.9–1.4)

 

1.2 (0.9–1.5)

 pREBOASBP

1.3 (1.1–1.5)

     

1.3 (1.1–1.5)

 

1.5 (1.3–1.7)

ASAT (μkat L−1)

 pREBOAETCO2

1.0 (0.8–1.3)

     

1.8 (1.3–2.5)

 

3.0 (1.8–4.9)

 pREBOASBP

1.1 (0.9–1.4)

     

2.4 (2.1–2.8)

 

4.5 (3.1–6.4)

CK (μkat L−1)

 pREBOAETCO2

19.3 (13.7–24.8)

     

22.3 (17.4–27.2)

 

28.3 (22.1–34.4)

 pREBOASBP

18.5 (14.9–22.1)

     

23.2 (18.9–27.6)

 

32.1 (26.2–38.0)

  1. Arterial and mesenteric venous blood gases and arterial blood samples during end-tidal carbon dioxide (ETCO2) targeted partial resuscitative endovascular balloon occlusion of the aorta (pREBOA, pREBOAETCO2, n = 10) and proximal systolic blood pressure targeted pREBOA (pREBOASBP, n = 10) in anesthetized, mechanically ventilated pigs. Data are means (95% confidence intervals); adenotes statistical difference between the groups
  2. pO2: partial pressure of oxygen; Mes. ven. pO2: mesenteric venous pO2; VO2: oxygen consumption; VCO2: carbon dioxide production; DO2: oxygen delivery; O2ER: oxygen extraction ratio; ALAT: alanine aminotransferase; ASAT: aspartate aminotransferase; CK: creatine kinase