Fig. 3

Body weight in gram. The control (mean [SD]; day 0: 224.9 [13.3], day 4: 239.5 [17.3], day 8: 267.8 [16.7], day 12: 276.0 [20.0]; p < 0.001), immobilisation (mean [SD]; day 0: 225.0 [11.4], day 4: 233.5 [12.9], day 8: 255.2 [16.3], day 12: 260.8 [16.5]; p < 0.001), inflammation (mean [SD]; day 0: 222.2 [13.0], day 4: 214.1 [19.5], day 8: 229.8 [17.5], day 12: 220.6 [15.3]; p < 0.001) as well as immobilisation and inflammation (mean [SD]; day 0: 223.8 [12.8], day 4: 213.0 [13.6], day 8: 230.0 [14.4], day 12: 221.2 [15.9]; p < 0.001) group showed a significant change over time. The increase over time in the control and immobilisation group led to significantly higher values in comparison with either the inflammation or immobilisation and inflammation group on days 4, 8 and 12 (p < 0.001 for all three timepoints and 3 comparisons). The number of identical symbols at the top of the error bars indicate the significance level: one < 0.05; two < 0.01 and three < 0.001. *Significant difference over time with the colour of the symbol indicating the respective group. ^#Significant difference to the control group at the specific time point. ⁺Significant difference to the immobilisation group at the specific time point. ^§Significant difference to the inflammation group at the specific time point