| Usual care N = 46 | Restricted volume N = 49 |
---|---|---|
Age (years) | 66 (45, 76) | 65 (52, 78) |
Male sex n (%) | 29 (63) | 30 (61) |
Weight (kg) | 72 (64, 92) | 80 (66, 88) |
Mean temperature (°C) | 37.5 ± 1.2 | 37.3 ± 1.3 |
Mean heart rate (beats/min) | 96 ± 20 | 96 ± 21 |
Mean respiratory rate (breaths/min) | 23 ± 6 | 22 ± 5 |
SpO2 (%) | 96 (95, 98) | 96 (94, 98) |
FiO2 | 0.21 (0.21, 0.32) | 0.21 (0.21, 0.3) |
GCS | 15 (15,15) | 15 (15, 15) |
Mean SBP (mmHg) | 87 ± 9 | 86 ± 9 |
Mean MAP (mmHg) | 64 ± 8 | 65 ± 7 |
Lactate (mmol/L) | 1.95 (1.25, 2.85) | 1.7 (1.1, 3.5) |
Charlson score | 2 (0, 5) | 2 (1, 4) |
APACHE II score | 14 (10, 19) | 15 (11, 20) |
SOFA score | 5 (4, 7) | 5 (3, 9) |
Non-CVS SOFA score | 3 (2, 5) | 3 (1, 6) |
Creatinine (ÎĽmol/L) | 130 (80, 173) | 112 (76, 160) |
Haematocrit T0 | 0.38 ± 0.07 | 0.38 ± 0.06 |
Infection source N (%) | Â | Â |
Respiratory | 18 (39) | 13 (27) |
Urinary | 8 (17) | 16 (33) |
Skin/soft tissue | 6 (13) | 6 (12) |
Bloodstream | 7 (15) | 3 (6) |
Abdominal/pelvis | 2 (5) | 5 (10) |
Other/unidentified | 5 (11) | 6 (12) |
Pre randomisation fluid volume (ml) | 1250 (1000, 2000) | 1400 (1000, 1500) |
Time from ED arrival (minutes) | 143 (89, 250) | 140 (103, 214) |