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Intensive Care Medicine Experimental

Table 3 Biomarker values

From: Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis

 

Standard

Restricted

 

N

Mean (SD)

Median (Q1, Q3)

N

Mean (SD)

Median (Q1, Q3)

ProANP (ng/ml)

T0

44

35 (27)

26 (17, 46)

46

41 (29)

33 (20, 58)

T3

44

31 (23)

24 (14, 44)

43

34 (30)

23 (14, 46)

T6

39

25 (19)

32 (18, 55)

42

27 (21)

23 (11, 34)

T24

39

35 (21)

23 (14, 42)

45

32 (18)

30 (16, 47)

Syndecan-1 (ng/ml)

T0

44

19.0 (26.7)

7.0 (5.0, 20.2)

46

19.5 (36.4)

5.5 (3.2, 16.8)

T3

44

19.3 (32.3)

6.9 (3.9, 18.4)

44

20.6 (37.8)

5.9 (2.8, 15.1)

T6

38

17.0 (23.2)

5.9 (3.9, 18)

41

18.7 (41.3)

5.1 (2.8, 10.8)

T24

39

17.9 (28.0)

7.6 (5.1, 12.9)

44

25.0 (46.8)

6.9 (4.7, 15.5)

Syndecan-4 (pg/ml)

T0

44

2853 (5595)

804 (510, 2136)

46

3189 (7021)

868 (483, 2156)

T3

44

3439 (6410)

1195 (502, 2388)

44

3773 (11,950)

826 (449, 1918)

T6

39

2407 (4030)

756 (411, 1628)

42

2494 (5723)

602 (361, 2134)

T24

39

2144 (4462)

542 (283, 1281)

45

3301 (8633)

776 (324, 1714)

Hyaluronan (ng/ml)

T0

44

920 (1688)

216 (73, 1123)

45

1046 (2700)

261 (74, 702)

T3

44

930 (2700)

144 (80, 543)

44

508 (1614)

152 (40, 377)

T6

39

671 (2096)

136 (58, 372)

42

561 (2249)

121 (33, 269)

T24

39

1397 (6422)

124 (36, 230)

45

978 (3217)

172 (43, 515)

Hep Sulphate (ng/ml)

T0

44

2650 (1687)

2264 (1481, 3361)

46

3123 (2265)

2248 (1601, 3853)

T3

44

2737 (1651)

2142 (1368, 4093)

44

2819 (1790)

2141 (1522, 4048)

T6

39

3028 (2711)

2064 (1381, 4048)

42

2995 (2335)

2118 (1138, 4536)

T24

39

2683 (1608)

2244 (1384, 3691)

45

3020 (1891)

2264 (1505, 4183)

ICAM-1 (pg/ml)

T0

44

1070 (953)

681 (456, 1272)

46

1179 (949)

856 (615, 1476)

T3

44

912 (748)

608 (451, 1070)

44

1004 (948)

633 (440, 1063)

T6

39

1332 (1855)

811 (480, 1362)

42

1401 (1381)

1150 (637, 1617)

T24

39

1075 (1088)

598 (361, 1363)

45

1191 (1251)

690 (326, 986)

VCAM-1 (pg/ml)

T0

44

3348 (2509)

3075 (1210, 4844)

46

3751 (2713)

3066 (1858, 4780)

T3

44

2781 (2905)

1745 (923, 3827)

44

2751 (2153)

2007 (1071, 4196)

T6

39

3913 (3936)

2235 (1680, 4765)

42

4581 (3361)

3549 (2345, 5830)

T24

39

2664 (3158)

1354 (920, 3618)

45

2785 (4209)

1176 (570, 2718)

E Selectin (ng/ml)

T0

44

49 (47)

30 (12, 87)

47

62 (71)

32 (13, 104)

T3

43

44 (38)

31 (16, 59)

41

55 (60)

31 (12, 89)

T6

39

47 (40)

34 (12, 74)

42

55 (55)

27 (10, 111)

T24

39

36 (27)

30 (14, 65)

45

45 (48)

23 (11, 66)

Resistin (ng/ml)

T0

44

140 (135)

103 (55, 146)

46

122 (205)

73 (31, 122)

T3

44

197 (327)

118 (60, 164)

44

177 (324)

104 (41, 171)

T6

39

137 (142)

101 (55, 151)

41

154 (253)

107 (38, 188)

T24

39

128 (157)

74 (35, 162)

45

133 (165)

90 (37, 139)

NGAL (pg/ml)

T0

44

501 (630)

286 (137, 517)

46

539 (641)

354 (158, 661)

T3

44

395 (462)

262 (155, 468)

43

397(405)

242 (137, 517)

T6

38

359 (279)

283 (145, 493)

42

615 (816)

341 (148, 594)

T24

38

369 (366)

230 (161, 486)

45

431 (447)

281 (151, 540)

IL-6 (ng/ml)

T0

44

58.7 (164.1)

1.6 (0.3, 21.9)

46

50.1 (146.7)

9.3 (2.9, 13.1)

T3

43

15.8 (38.0)

1.0 (0.3, 8.1)

42

13.6 (45.5)

2.9 (0.1, 18.1)

T6

39

4.9 (10.5)

0.8 (0.1, 4.5)

42

12.2 (41.4)

3.3 (0.1, 16.6)

T24

39

0.7 (1.5)

0.1 (0.05, 4.5)

45

5.5 (11.2)

0.1 (0.02, 0.4)

IL-10 (ng/ml)

T0

42

254 (1386)

3.5 (0.13, 54)

45

265 (796)

0.13 (0.13, 62)

T3

43

159 (591)

11.3 (0.13, 67)

41

131 (492)

0.13 (0.13, 38)

T6

37

42 (64)

15.3 (0.13, 39)

39

97 (232)

7.87 (0.13, 84)

T24

38

2.9 (8.5)

0.13 (0.13, 0.13)

44

128 (495)

0.13 (0.13, 38)

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