Fig. 2

Occurrence of septic shock. A Significant drop in blood pressure at the time of septic shock, which here requires a MAP < 60 mmHg. MAP (BL) 74 ± 3 mmHg to MAP (S) 54 ± 1 mmHg. n = 10, Wilcoxon matched-pairs signed rank test. B Blood pressure during treatment period with a MAP goal ≥ 65 mmHg. n = 10. C Significant increase in serum lactate concentration from baseline (1.38 ± 0.34 mmol/L) to shock time (3.76 ± 0.65 mmol/L) with persistent hyperlactatemia after implementation of the 1 h-bundle (S + 1 2.58 ± 0.40 mmol/L) and over the treatment period. n = 10, rm ANOVA/Geisser–Greenhouse/Bonferroni. **P < 0.01, ***P < 0.001. BL = baseline, S = shock. mean ± SEM