Fig. 3
Changes in basic and extended hemodynamic parameters measured via thermodilution. A Vasopressor requirement middled per hour during the experiment with an interindividual variation and increase over the treatment period. n = 9. Boxplot (Tukey). B Significant increase of heart rate by onset of septic shock from BL (105 ± 7 min−1) to shock (181 ± 11 min−1). n = 10, paired t test. C Significant decrease in cardiac index in septic shock and significant increase after beginning of therapy. n = 10. No significant changes in SVRI at shock time; but significant loss of SVRI after first hour of therapy. n = 10, rm ANOVA/Geisser–Greenhouse/Bonferroni. D Significant decrease in GEDI by onset of septic shock (BL 681 ± 21 mL/m2; S 418 ± 25 mL/m2) without significant increase after implementation of the 1 h-bundle. n = 10, rm ANOVA/Geisser–Greenhouse/Bonferroni. E Cardiac output significantly decreased in septic shock and increased with start of therapy shown by changes in CPI as well as the changes in GEF. n = 10, rm ANOVA/Geisser–Greenhouse/Bonferroni. F Changes in pulmonary parameters (EVLI and PVPI) not significant; ns. n = 10, rm ANOVA/Geisser–Greenhouse/Bonferroni. ns not significant, *P < 0.05, ***P < 0.001. BL = baseline, S = shock. mean ± SEM