Fig. 5

Immunological response to the septic inoculum by time of clinical occurrence of septic shock and marker of glycocalyx damage. A Evidence of a significant increase in proinflammatory IL-6 at the time of shock (BL: 6.74 ± 2.23 pg/mL, S: 36.76 ± 5.03 pg/mL). n = 6, paired t test. B TNFalpha level did not increase by clinical occurrence of septic shock n = 6, paired t test. C IL-1ß also did not increase by clinical onset of septic shock, n = 6, paired t test. D Significant decrease of IFNalpha levels (BL: 4.95 ± 1.00 pg/mL to S: 1.88 ± 0.35 pg/mL), n = 6, paired t test. E Syndecan-1 level did not significantly increase from 1.49 ± 0.1 ng/mL (BL) to S + 8 to the end of the experiment (S + 8, 1.61 ± 0.1 ng/mL), n = 10, paired t test, mean ± SEM. F Microbiological analyse of the faecal inoculum with determination of CFU/mL. n = 6. *P < 0.01, **P < 0.001. BL = baseline, S = shock. mean ± SEM