Table 1 Systematic literature review of porcine septic shock models used from the years 2002–2022 and their characteristics
Author | MAP < 65 mmHg | Lactate ≥ 2 mmol/L | Weight (kg) | Sex | Sepsis induction (faecal amount) |
|---|---|---|---|---|---|
Marx et al., 2002 | Yes | No | 20.8 ± 1.8 | e | 1 g/kg i.p. |
Hiltebrand et al., 2003 | Yes | No | 20–25 | – | 20 g i.p. |
Krejci et al., 2003 | Yes | No | 22–28 | – | 20 g i.p. |
Hiltebrand et al., 2004 | Yes | No | 20–25 | – | 20 g i.p. |
Marx et al., 2004 | Yes | No | 23.1 ± 2.4 | f | 0.75 g/kg i.p. |
Marx et al., 2006 | No | No | 22.9 ± 2.8 | f | 0.75 g/kg i.p. |
Krejci et al., 2006 | Yes | No | 22–28 | – | 20 g i.p. |
Schuerholz et al., 2006 | No | No | 21.2 ± 1.5 | – | 0.75 g/kg i.p. |
Azevedo et al., 2007 | Yes | No | 40–45 | – | 1.5 g/kg i.p. |
Hiltebrand et al., 2007 | No | No | 28–32 | – | 20 g i.p. |
Krejci et al., 2007 | No | No | 28–32 | – | 3 g/kg i.p. |
Barth et al., 2008 | No | No | – | e | Faeces i.p. |
Hauser et al., 2009 | No | No | 46–59 | e | 0.05 g/kg i.p. |
Simon et al., 2009 | No | No | – | – | 1 g/kg i.p. |
Sykora et al., 2009 | Yes | No | 32–38 | e | 0.5 g/kg i.p. |
Wauters et al., 2010 | No | No | 40.5 ± 4 | f | 0.8 g/kg i.p. |
Rosário et al., 2011 | Yes | No | 35–45 | – | 0,75 g/kg i.p. |
Kuncová et al., 2011 | No | No | – | e | 0.5 g/kg i.p. |
Regueira et al., 2012 | No | No | 36–46 | e | 1 g/kg i.p. |
Ji et al., 2012 | Yes | No | 26–35 | f | 1 g/kg i.p. |
Derive et al., 2013 | No | No | 30–40* | m | 1.5 g/kg i.p. |
Kieslichova et al., 2013 | Yes | No | 36* | – | CLP 3 cm |
Li et al., 2013 | Yes | No | 31 ± 5 | m | 0.5 g/kg i.p. |
Schmidt et al., 2013 | Yes | No | 29.8 ± 3.5 | f | 0.75 g/kg i.p. |
Corrêa et al., 2014 | Yes | No | 40–43 | m | 2 g/kg i.p. |
Jarkovska et al., 2015 | Yes | No | 39 ± 6 | e | 1 g/kg i.p. |
Nußbaum et al., 2016 | No | No | 65–73 | m | 1 g/kg dissolved in 500 mL, 3 mL/kg i.p. |
Corrêa et al., 2017 | No | No | – | – | 1–2 g/kg i.p. |
Nußbaum et al., 2017 | No | No | 55–62 | m | 1 g/kg i.p. |
Ospina-Tascón et al., 2017 | Yes | No | 35–42 | f | 1.5 g/kg i.p. |
Laroye et al., 2018 | No | No | 40–60 | m | 3 g/kg i.p. |
Jarkovska et al., 2018 | Yes | No | 43.9 ± 5.8 | e | 1 g/kg i.p. |
Ferrario et al., 2019 | Yes | No | 42.3 ± 3.9 | e | 3 g/kg i.p. |
Kurtz et al., 2019 | No | No | 40 | m | 0.5 g/kg i.p. |
Carrara et al., 2019 | Yes | No | 43.8 ± 3.9 | e | 3 g/kg i.p. |
Park et al., 2019 | Yes | No | 49 ± 8 | m | 1 g/kg i.p. |
Chvojka et al., 2020 | Yes | No | 54 | e | 2 g/kg i.p. |
Horak et al., 2020 | Yes | No | 40–46 | e | 1 g/kg i.p. |
Merz et al., 2020 | Yes | No | 65–73 | m | Faeces i.p. |
Al-Obeidallah et al., 2021 | Yes | No | 40 ± 6 | e | 1 g/kg i.p. |
Bollen Pinto et al., 2022 | Yes | No | 42.3 ± 3.9 | e | 3 g/kg i.p. |
Garcia et al., 2022 | Yes | No | 49 ± 5 | e | 3 g/kg i.p. |
Messerer et al., 2022 | No | No | 54–89 | e | 1.5 g/kg i.p. |
Rutai et al., 2022 | Yes | Yes | 35 ± 9* | e | 0.6 g/kg i.p. |