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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial

Fig. 2

Perioperative selenium status and inflammation. A Selenium treatment (blue) increased serum selenium and selenoprotein P (SELENOP) concentrations compared to placebo (black). However, this increase did not translate to altered glutathione peroxidase 3 (GPx3) activity. Gray coloration indicates values below the lower reference limit (selenium and SELENOP) and above the upper reference limit (GPx3). Reference ranges were used as published elsewhere. B Interleukin- (IL-) 6 levels reflect a significant inflammatory reaction following cardiac surgery. C Receiver operating characteristic (ROC) analyses on the predictive potential of the three selenium biomarkers at baseline regarding 6-month survival after cardiac surgery. Areas under the curves (AUCs) are listed in brackets. GPx3 outperformed the other two biomarkers of selenium status. Asterisks (*) indicate statistical significance, and waves (≈) indicate a trend. BL baselinẹ, ICU intensive care unit

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