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Intensive Care Medicine Experimental

Table 4 Univariate models of cerebrovascular reactivity measures for transition in outcome

From: Time spent above optimal cerebral perfusion pressure is not associated with failure to improve in outcome in traumatic brain injury

Model

AUC (95% CI)

AIC

p value

Nagelkerke's R2

1 month → 3 months

 CPPopt–PRx

0.489 (0.369–0.602)

143.1

0.5732

0.002

  % Time ΔCPPopt–PRx > 5 mmHg

0.560 (0.447–0.669)

141.6

0.2651

0.021

  % Time ΔCPPopt–PRx > 10 mmHg

0.610 (0.501–0.719)

140.3

0.1218

0.039

  % Time ΔCPPopt–PRx < −5 mmHg

0.516 (0.370–0.595)

142.9

0.4886

0.004

  % Time ΔCPPopt–PRx < −10 mmHg

0.497 (0.393–0.614)

143.1

0.5777

0.003

  % Time CPP > ULR–PRx

0.553 (0.441–0.663)

142.1

0.2904

0.016

  % Time CPP < LLR–PRx

0.572 (0.457–0.684)

140.9

0.2291

0.030

 CPPopt–PAx

0.492 (0.399–0.619)

143.1

0.5824

0.002

  % Time ΔCPPopt–PAx > 5 mmHg

0.617 (0.507–0.723)

139.0

0.1166

0.055

  % Time ΔCPPopt–PAx > 10 mmHg

0.633 (0.520–0.744)

137.5

0.1197

0.073

  % Time ΔCPPopt–PAx < −5 mmHg

0.520 (0.405–0.638)

143.1

0.4855

0.002

  % Time ΔCPPopt–PAx < −10 mmHg

0.552 (0.427–0.666)

143.0

0.2832

0.003

  % Time CPP > ULR–PAx

0.620 (0.509–0.726)

134.7

0.1365

0.108

  % Time CPP < LLR–PAx

0.649 (0.543–0.751)

131.9

0.1113

0.140

 CPPopt–RAC

0.507 (0.381–0.608)

142.8

0.5257

0.005

  % Time ΔCPPopt–RAC > 5 mmHg

0.584 (0.473–0.708)

141.2

0.1945

0.027

  % Time ΔCPPopt–RAC > 10 mmHg

0.603 (0.490–0.716)

137.7

0.1348

0.071

  % Time ΔCPPopt–RAC < −5 mmHg

0.537 (0.421–0.650)

142.9

0.3713

0.005

  % Time ΔCPPopt–RAC < −10 mmHg

0.571 (0.460–0.680)

142.4

0.2131

0.011

  % Time CPP > ULR–RAC

0.584 (0.467–0.688)

138.4

0.1773

0.062

  % Time CPP < LLR–RAC

0.585 (0.470–0.695)

138.6

0.2181

0.060

3 months → 6 months

 CPPopt–PRx

0.597 (0.475–0.716)

125.1

0.1076

0.044

  % Time ΔCPPopt–PRx > 5 mmHg

0.605 (0.482–0.720)

125.9

0.1118

0.033

  % Time ΔCPPopt–PRx > 10 mmHg

0.593 (0.464–0.720)

125.6

0.1119

0.037

  % Time ΔCPPopt–PRx < −5 mmHg

0.547 (0.425–0.665)

127.4

0.3198

0.013

  % Time ΔCPPopt–PRx < −10 mmHg

0.521 (0.401–0.639)

128.0

0.4112

0.004

  % Time CPP > ULR–PRx

0.601 (0.472–0.730)

120.7

0.1044

0.101

  % Time CPP < LLR–PRx

0.511 (0.386–0.642)

128.3

0.4569

0

 CPPopt–PAx

0.544 (0.411–0.668)

127.0

0.3204

0.018

  % Time ΔCPPopt–PAx > 5 mmHg

0.679 (0.561–0.790)

121.0

0.0483

0.098

  % Time ΔCPPopt–PAx > 10 mmHg

0.654 (0.523–0.778)

119.8

0.0746

0.112

  % Time ΔCPPopt–PAx < −5 mmHg

0.653 (0.538–0.762)

122.6

0.0399

0.076

  % Time ΔCPPopt–PAx < −10 mmHg

0.626 (0.502–0.742)

124.5

0.0958

0.051

  % Time CPP > ULR–PAx

0.622 (0.502–0.741)

125.2

0.0795

0.042

  % Time CPP < LLR–PAx

0.543 (0.425–0.663)

127.4

0.3072

0.013

 CPPopt–RAC

0.534 (0.404–0.662)

127.1

0.3434

0.017

  % Time ΔCPPopt–RAC > 5 mmHg

0.654 (0.537–0.768)

121.3

0.0511

0.093

  % Time ΔCPPopt–RAC > 10 mmHg

0.623 (0.491–0.745)

123.2

0.0882

0.068

  % Time ΔCPPopt–RAC < −5 mmHg

0.603 (0.478–0.721)

125.2

0.1067

0.042

  % Time ΔCPPopt–RAC < −10 mmHg

0.558 (0.427–0.671)

127.2

0.2661

0.015

  % Time CPP > ULR–RAC

0.611 (0.487–0.736)

126.2

0.1013

0.029

  % Time CPP < LLR–RAC

0.471 (0.347–0.585)

128.3

0.6802

0

1 month → 6 months

 CPPopt–PRx

0.531 (0.422–0.648)

145.6

0.3472

0.014

  % Time ΔCPPopt–PRx > 5 mmHg

0.632 (0.523–0.740)

140.6

0.0281

0.076

  % Time ΔCPPopt–PRx > 10 mmHg

0.650 (0.542–0.746)

139.6

0.0189

0.089

  % Time ΔCPPopt–PRx < −5 mmHg

0.587 (0.471–0.694)

143.9

0.1122

0.035

  % Time ΔCPPopt–PRx < −10 mmHg

0.566 (0.451–0.678)

144.9

0.1757

0.024

  % Time CPP > ULR–PRx

0.508 (0.381–0.600)

145.4

0.4488

0.016

  % Time CPP < LLR–PRx

0.584 (0.468–0.693)

143.3

0.1161

0.043

 CPPopt–PAx

0.529 (0.422–0.640)

145.6

0.3366

0.015

  % Time ΔCPPopt–PAx > 5 mmHg

0.664 (0.559–0.765)

138.3

0.0147

0.105

  % Time ΔCPPopt–PAx > 10 mmHg

0.675 (0.564–0.772)

134.2

0.0231

0.152

  % Time ΔCPPopt–PAx < −5 mmHg

0.590 (0.481–0.705)

144.5

0.1103

0.029

  % Time ΔCPPopt–PAx < −10 mmHg

0.609 (0.502–0.717)

145.0

0.0599

0.022

  % Time CPP > ULR–PAx

0.551 (0.344–0.569)

145.9

0.2483

0.011

  % Time CPP < LLR–PAx

0.665 (0.556–0.766)

137.0

0.0210

0.120

CPPopt–RAC

0.532 (0.415–0.645)

145.6

0.3537

0.015

  % Time ΔCPPopt–RAC > 5 mmHg

0.643 (0.535–0.746)

138.9

0.0214

0.097

  % Time ΔCPPopt–RAC > 10 mmHg

0.651 (0.542–0.753)

135.3

0.0221

0.140

  % Time ΔCPPopt–RAC < −5 mmHg

0.629 (0.516–0.740)

142.1

0.0282

0.059

  % Time ΔCPPopt–RAC < −10 mmHg

0.637 (0.528–0.743)

143.2

0.0246

0.044

  % Time CPP > ULR–RAC

0.509 (0.397–0.620)

146.6

0.4576

0.001

  % Time CPP < LLR–RAC

0.572 (0.465–0.682)

143.6

0.1566

0.039

  1. All p values have been adjusted using the False Discovery Rate (FDR) method
  2. AIC Akaike information criterion, AMP pulse amplitude of ICP, AUC area under the curve, CI confidence interval, CPP cerebral perfusion pressure, CPPopt cerebral perfusion pressure optimum, ΔCPPopt CPP—CPPopt, ICP intracranial pressure, LLR lower limit of reactivity, mmHg millimeters of mercury, PAx pulse amplitude index, PRx pressure reactivity index, RAC correlation (R) between slow-waves of AMP (A) and CPP (C), ULR upper limit of reactivity
  3. Bolded p values are those reaching statistical significance, p < 0.05
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