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Intensive Care Medicine Experimental

Table 2 Histoarchitecture of the hypothalamus score

From: Pressure-support compared with pressure-controlled ventilation mitigates lung and brain injury in experimental acute ischemic stroke in rats

 

PCV-PEEP2

PSV-PEEP2

PCV-PEEP5

PSV-PEEP5

Necrosis (0–16)

3.0 (2.0–4.0)*

1.0 (0.0–1.0)

6.0 (4.0–10.0)#

1.0 (0.0–1.0)

Hemorrhage (0–16)

4.0 (3.0–4.0)*

0.0 (0.0–1.0)

9.0 (6.0–14.0)#

1.0 (0.0–1.0)

Neuropil edema (0–16)

8.0 (6.0–9.0)*

2.0 (1.0–2.0)

9.0 (6.0–14.0)#

2.0 (1.0–2.0)

CD11b + dentate gyrus (0–16)

4.0 (3.0–4.0)

1.0 (1.0–4.0)

6.0 (3.5–7.5)#

1.0 (1.0–2.0)

CD11b + pyramidal (0–16)

8.0 (6.0– 9.0)*

2.0 (2.0–2.0)

8.0 (5.0–12.0)#

1.0 (1.0–2.0)

CD45 + microglia (0–16)

4.0 (4.0–8.0)*

2.0 (1.0–2.0)

3.0 (2.0–4.0)

1.0 (1.0–2.0)

  1. Cumulative score representing hypothalamus injury from necrosis, hemorrhage, neuropil edema, CD11b + dentate gyrus, CD11b + pyramidal, and CD45 + microglia. PCV, pressure-controlled ventilation; PEEP, positive end-expiratory pressure; PSV, pressure-support ventilation. Values are given as medians (interquartile ranges) of 6 animals in each group. Comparisons were done using Kruskal–Wallis test followed by Dunn’s multiple comparisons test (p < 0.05). *Versus PSV-PEEP2 group; #versus PSV-PEEP5 group
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