Fig. 5

Time-varying trajectories of metabolic alterations. The figure summarizes the course of metabolic markers over time for every conducted filter run. Only values were included, which were measured during a CRRT run. Maximal run time was 72 h as per institutional protocol. Clogging filters (blue line) showed persistently higher sodium concentrations in the plasma A with increasing bicarbonate levels over time B. Corrected_Alb Ca was only slightly increased in filters allocated to the clogging group C. Whereas calcium substitution (CaSR) did not differ between overall clogging and non-clogging filters at the beginning of CRRT, a decline of substitution rate could be observed in filters with first onset of clogging (first-clogging, blue line in D)