Overall | Non-clogging | Clogging | p value | |
---|---|---|---|---|
n = 53 | n = 35 | n = 18 | (Non-clogging vs. clogging) | |
Demographics | ||||
Age | 61.0 [56.0–69.0] | 61.0 [56.0–70.0] | 63.0 [58.2–67.5] | 0.851 |
Weight | 89.0 [75.0–100.0] | 85.0 [73.9–100.0] | 90.0 [80.0–109.0] | 0.387 |
Height | 175.0 [165.0–181.0] | 173.0 [160.0–180.0] | 177.5 [170.0–184.8] | 0.049 |
Male | 39 (74) | 24 (69) | 15 (83) | 0.409 |
SOFA Score | 14.0 [12.0–16.0] | 13.0 [10.5–15.0] | 15.0 [14.2–17.8] | 0.006 |
SAPS II | 55.0 [40.0–65.0] | 50.0 [37.0–63.5] | 60.5 [52.0–67.2] | 0.126 |
APACHE II | 23.0 [19.0–29.0] | 22.0 [16.0–28.0] | 26.0 [23.0–28.8] | 0.098 |
Comorbidities | ||||
Ischemic Heart Disease | 8 (15) | 7 (20) | 1 (6) | 0.324 |
Chronic Heart Failure | 7 (13) | 2 (6) | 5 (28) | 0.069 |
Peripheral Vascular Disease | 3 (6) | 2 (6) | 1 (6) | 1 |
Chronic Arterial Hypertension | 17 (32) | 12 (34) | 5 (28) | 0.865 |
Diabetes mellitus Type 1 or 2 | 14 (26) | 10 (29) | 4 (22) | 0.867 |
Diabetes mellitus with End Organ Damage | 1 (2) | 1 (3) | 0 (0) | 1 |
Cerebrovascular Disease | 5 (9) | 3 (9) | 2 (11) | 1 |
Chronic Obstructive Pulmonary Disease | 3 (6) | 3 (9) | 0 (0) | 0.515 |
Peptic Ulcer Disease | 1 (2) | 1 (3) | 0 (0) | 1 |
Mild Liver Disease | 2 (4) | 2 (6) | 0 (0) | 0.785 |
Moderate to Severe Liver Disease | 3 (6) | 2 (6) | 1 (6) | 1 |
Moderate to Severe Chronic Kidney Disease | 8 (15) | 6 (17) | 2 (11) | 0.86 |
Solid Tumor (Localized) | 5 (9) | 4 (11) | 1 (6) | 0.844 |
Solid Tumor (Metastatic) | 1 (2) | 1 (3) | 0 (0) | 1 |
Leukemia | 3 (6) | 3 (9) | 0 (0) | 0.515 |
Lymphoma | 1 (2) | 1 (3) | 0 (0) | 1 |
Immunisupression | 4 (8) | 3 (9) | 1 (6) | 1 |
Organ support and treatment during ICU stay | ||||
Organ support | ||||
Vasopressors | 53 (100) | 35 (100) | 18 (100) | 1 |
HFO/NIV | 18 (34) | 13 (37) | 5 (28) | 0.707 |
IMV | 53 (100) | 35 (100) | 18 (100) | 1 |
ECCO2R | 3 (6) | 2 (6) | 1 (6) | 1 |
ECMO | 13 (25) | 7 (20) | 6 (33) | 0.465 |
Prone Position | 41 (77) | 26 (74) | 15 (83) | 0.69 |
iNO | 19 (36) | 11 (31) | 8 (44) | 0.527 |
Drug Therapies | ||||
Corticosteroids | 37 (70) | 26 (74) | 11 (61) | 0.501 |
Tocilizumab | 2 (4) | 2 (6) | 0 (0) | 0.785 |
Hydroxychloroquine | 11 (21) | 7 (20) | 4 (22) | 1 |
Ritonavir/lopinavir | 4 (8) | 3 (9) | 1 (6) | 1 |
Remdesivir | 22 (42) | 18 (51) | 4 (22) | 0.08 |
Cytosorb | 1 (2) | 0 (0) | 1 (6) | 0.732 |
PEX | 1 (2) | 1 (3) | 0 (0) | 1 |
Baricitinib | 1 (2) | 1 (3) | 0 (0) | 1 |
Outcome parameters | ||||
LOS ICU | 24.0 [12.0, 32.0] | 23.0 [12.0, 32.0] | 29.5 [13.5, 45.2] | 0.198 |
LOS Hospital | 41.0 [28.5, 44.2] | 36.0 [26.0, 42.0] | 42.0 [40.0, 45.0] | 0.53 |
Survivor 28 days | 20 (40) | 12 (36) | 8 (47) | 0.67 |
Survivor 6 months | 10 (23) | 6 (21) | 4 (27) | 0.945 |