Fig. 2
From: Capillary leak and endothelial permeability in critically ill patients: a current overview
Diagnostic approach to capillary leak syndrome (CLS): both serological markers related to glycocalyx shedding and vascular barrier signaling, as well as the vascular leak index can hint towards a CLS phenotype. More nuanced diagnostic approaches comprise bioelectrical impedance analysis (BIA), transpulmonary thermodilution (TPTD), PiCCOâ„¢ (pulse index continuous cardiac output), and intravital microscopy