Sepsis and obesity: a scoping review of diet-induced obesity murine models

Intensive Care Medicine Experimental

Table 2 Summary of characteristics of sepsis model

Authors	Method of sepsis	Route of infection	Dose	Endpoint (h)	Antibiotics	Fluids	Analgesia
DeMartini [24]	CLP	IP	Double puncture; 22G	6	Imipenem (25 mg/kg)	Sterile saline, SC; (0.6 mL)	NR
Frydrych [25]	CLP	IP	Double puncture; 20G	28 days	NR	NR	NR
Gomes [26]	CLP	IP	Single puncture; 21G	7 days	NR	Sterile saline, SC; (0.5 mL/10 g)	NR
Goosses [27]	CLP	IP	Needle not specified	1, 5 days	Yes^a	Yes^a, IV	Yes^a
Kaplan [28]	CLP	IP	Double puncture; 21G	1–30	NR	Sterile saline, SC; (0.6 mL)	NR
Kaplan [29]	CLP	IP	Double puncture; 22G	6	NR	Sterile saline, SC; (0.6 mL)	NR
Khan [30]	CLP	IP	Single puncture; 18G	6	NR	LR, SC before surgery; (2 mL) LR, IV^b and 4 h later	Yes^a
Lewis [31]	CS	IP	500 μL of CS in 10% glycerol	14 days	NR	NR	NR
Panpetch [32]	CLP	IP	Double puncture; 21G	24	NR	NR	Fentanyl, SC^b and 6 h; (0.03 mg/kg)
Rivera [33]	CLP	IP	Triple puncture; 20G	6	NR	Saline^b; (1 mL)	NR
Siegl [34]	CLP	IP	Single puncture; 23G	10 days	NR	Sterile saline, SC^b; (1 mL)	NR
Souza [35]	CLP	IP	NR	24	NR	NR	NR
Strandberg [36]	S. aureus	IV	5 × 10⁷ CFU	24, 5–7 or 17 days	NR	NR	NR
Su [37]	CLP	IP	Single puncture; 23G	12, 24	NR	Sterile saline, SC^b; (4 mL/kg)	0.25% bupivacaine; (100 µL)
Vankrunkelsven [38]	CLP	IP	18G	5 days	Imipenem/Cilastatin	IV^a	Buprenorphine
Williamson [39]	CLP	IP	Double puncture; 22G	18	Imipenem (25 mg/kg)	Normal saline, SC; (1 mL)	NR
Yeh [40]	CLP	IP	Single puncture; 23G	12, 24	NR	Sterile saline, SC^b; (4 mL/kg BW)	0.25% bupivacaine; (100 µL)

NR not reported, MRSA methicillin-resistant Staphylococcus aureus, IV intravenous, SC subcutaneous, CLP cecal ligation and puncture, IP intraperitoneal, CS cecal slurry, LR lactated ringers, BW body weight
^aNo further specifications given
^bGiven post-surgery