Fig. 4

Transition of host response subphenotypes between baseline and follow-up time points. 103 participants (70%) were in the hypoinflammatory subphenotype at baseline. 91% remained hypoinflammatory at follow-up (39% received glucocorticoids) and 9% became hyperinflammatory (44% received glucocorticoids). 45 participants were hyperinflammatory at baseline of whom 53% remained hyperinflammatory (57% received glucocorticoids) and 47% became hypoinflammatory (58% received glucocorticoids). GCs, glucocorticoids; hypo, hypoinflammatory subphenotype; hyper, hyperinflammatory subphenotype