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Intensive Care Medicine Experimental

Table 1 Demographic data and baseline characteristics of animals

From: Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model

 

Totala (n = 18)

FCVa (n = 9)

PCVa (n = 9)

Estimate with 95% CIb

p-valuec

Demographic data

 Weight

54 (51–67)

52 (49–57)

56 (51–70)

− 5 (− 21 to 2)

0.1840

 Sex [female]

5/18 (27.8%)

3/9 (33.3%)

2/9 (22.2%)

 

1

Haemodynamic parameters

 HR [/min]

70 (66–76)

67 (65–74)

72 (69–76)

− 5 (− 18 to 4)

0.1995

 MAP [mmHg]

79 (74–84)

81 (75–85)

77 (71–81)

4 (− 4 to 12)

0.2689

 CVP [mmHg]

13 (11–16)

14 (11–16)

12 (12–13)

1 (− 4 to 4)

0.8239

 MPAP [mmHg]

26 (24–28)

27 (25–28)

25 (24–27)

1 (− 5 to 4)

0.6258

 PCWP [mmHg]

15 (13–17)

15 (14–17)

14 (13–16)

1 (− 4 to 3)

0.7216

 CI [l/min/m2]

5.8 (4.8–6.8)

5.6 (4.7–6.9)

5.9 (5.3–6.5)

− 0.6 (− 1.9 to 1.0)

0.4363

 PVRI [dyn·s/cm5/m2]

130 (110–177)

145 (113–208)

125 (108–151)

26 (− 23 to 89)

0.3865

 SVRI [dyn·s/cm5/m2]

847 (670–1031)

1014 (841–1050)

734 (624–875)

228 (− 23 to 533)

0.0503

Respiratory parameters

 RR [/min]

35 (32–39)

34 (32–39)

36 (32–38)

0 (− 6 to 6)

0.9292

 VT [ml/kg]

7.0 (7.0–7.1)

7.0 (7.0–7.1)

7.0 (7.0–7.1)

0.0 (− 0.1 to 0.1)

0.8945

 MV [l/min]

15.1 (12.8–16.0)

14.2 (11.4–15.8)

15.5 (14.1–16.0)

− 1.6 (− 4.7 to 1.0)

0.3770

 Ppeak [cmH2O]

22 (21–25)

22 (21–23)

22 (21–28)

− 2 (− 7 to 2)

0.4227

 PEEP [cmH2O]

5

5

5

  

 ΔP [cmH2O]

17 (16–20)

17 (16–18)

17 (16–23)

− 2 (− 7 to 2)

0.4227

 C [ml/cmH2O]

36.6 (32.6–43.1)

37.0 (33.2–39.6)

35.8 (32.4–49.5)

− 1.4 (− 12.4 to 6.3)

0.8252

 CCalc [ml/cmH2O]

23.2 (20.8–24.3)

23.1 (20.6–25.6)

23.3 (21.3–24.0)

0 (− 3.8 to 4.6)

0.9647

 R [cmH2O·s/l]

6.8 (6.6–7.3)

6.8 (6.7–7)

6.8 (6.6–7.4)

0.0 (− 1.7 to 0.6)

1

 MP [J/min]

22.7 (18.1–26.8)

22.3 (16.6–24.6)

24.3 (21.0–31.3)

− 4.9 (− 13.4 to 1.8)

0.2224

 PaCO2 [mmHg]

43 (42–45)

43 (41–45)

43 (42–45)

0 (− 3 to 3)

1

 PaO2 [mmHg]

116 (112–125)

125 (123–132)

114 (105–115)

15 (6 to 22)

0.017*

Metabolic parameters

 pH

7.38 (7.36–7.40)

7.37 (7.34–7.40)

7.39 (7.38–7.40)

− 0.02 (− 0.05 to 0.02)

0.4265

 Hb [mg/dl]

8.8 (8.5–9.12)

8.9 (8.5–9.3)

8.6 (8.5–8.9)

0.2 (− 0.5 to 0.8)

0.6243

 Lac [mg/dl]

12 (8.5–16)

12 (10–13)

12 (7–17)

0 (− 5 to 5)

1

 SvO2 [%]

62 (56–63)

60 (56–63)

63 (57–63)

− 2 (− 7 to 3)

0.5457

  1. C displayed compliance from the ventilator, CCalc calculated static compliance, CI cardiac index, CVP central venous pressure, FCV flow-controlled ventilation, Hb arterial hemoglobin level, HR heart rate, Lac arterial lactate level, MAP mean arterial pressure, MP mechanical power, MPAP mean pulmonary arterial pressure, MV respiratory minute volume, PaCO2 arterial partial pressure of carbon dioxide, PaO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PCWP pulmonary capillary wedge pressure, PEEP positive end-expiratory pressure, pH arterial potential of hydrogen, Ppeak peak pressure, PVRI pulmonary vascular resistance index, R resistance, RR respiratory rate, SvO2 mixed venous oxygen saturation, SVRI systemic vascular resistance index, VT tidal volume, ΔP driving pressure (= peak pressure – positive end-expiratory pressure)
  2. aBinary data are presented as no./total no. (%), continuous data as medians (25th to 75th percentile)
  3. bOdds ratios for binary variables and estimated median difference for continuous variables
  4. cAssessed by Fisher’s exact test for categorical variables and Wilcoxon rank sum test for continuous variables, significant differences (p < 0.05) are marked with an asterisk
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