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Intensive Care Medicine Experimental

Table 2 Course of respiratory parameters during intra-abdominal hypertension with estimated differences between groups

From: Individualised flow-controlled ventilation reduces applied mechanical power and improves ventilation efficiency in a porcine intra-abdominal hypertension model

IAH

FCVa (n = 9)

PCVa (n = 9)

Estimate with 95% CIb

p-valuec

VT [ml/kg]

    

 Grade 0

9.8

7.1

2.7 (1.7 to 3.7)

 < 0.001*

 Grade 1

8.6

7.0

1.5 (0.6 to 2.4)

0.0039*

 Grade 2

7.7

7.0

0.7 (− 0.1 to 1.4)

0.0941

 Grade 3

7.6

7.0

0.5 (− 0.4 to 1.4)

0.2606

RR [/min]

    

 Grade 0

14

34

− 20 (− 23 to − 16)

 < 0.001*

 Grade 1

16

34

− 18 (− 21 to − 14)

 < 0.001*

 Grade 2

18

34

− 15 (− 19 to 11)

 < 0.001*

 Grade 3

19

33

− 14 (− 18 to − 10)

 < 0.001*

MV [l/min]

    

 Grade 0

7.5

14.8

− 7.4 (− 9.1 to − 5.6)

 < 0.001*

 Grade 1

7.4

14.5

− 7.0 (− 8.8 to − 5.3)

 < 0.001*

 Grade 2

7.6

14.1

− 6.6 (− 8.2 to − 4.9)

 < 0.001*

 Grade 3

7.8

14.2

− 6.4 (− 8.0 to − 4.8)

 < 0.001*

MP [l/min]

    

 Grade 0

10.1

28.9

− 18.8 (− 23.8 to − 13.8)

 < 0.001*

 Grade 1

17.0

41.7

− 24.7 (− 31.4 to − 18.0)

 < 0.001*

 Grade 2

22.0

51.2

− 29.2 (− 37.2 to − 21.3)

 < 0.001*

 Grade 3

25.9

57.6

− 31.7 (− 39.1 to − 24.3)

 < 0.001*

PEEP [mmHg]

    

 Grade 0

3

5

− 2 (− 2 to − 2)

0.9804

 Grade 1

10

9

1 (0 to 2)

0.9539

 Grade 2

15

14

2 (− 1 to 4)

0.1890

 Grade 3

18

16

2 (− 1 to 4)

0.1924

Ppeak [mmHg]

    

 Grade 0

21

20

1 (− 1 to 3)

0.1935

 Grade 1

33

29

4 (1 to 6)

0.0141*

 Grade 2

40

37

4 (1 to 6)

0.0045*

 Grade 3

46

41

5 (2 to 7)

0.0034*

Pes [cmH2O]

    

 Grade 0

9.9

10.7

− 0.7 (− 3.2 to 1.7)

0.5609

 Grade 1

15.4

14.9

0.5 (− 3.8 to 4.7)

0.8395

 Grade 2

19.5

17.8

1.7 (− 3.6 to 7.0)

0.5417

 Grade 3

22.9

19.6

3.4 (− 2.4 to 9.1)

0.2654

C [ml/cmH2O]

    

 Grade 0

27.2

38.7

− 11.5 (− 18.8 to − 4.2)

0.0072*

 Grade 1

19.4

25.1

− 5.6 (− 9.7 to − 1.5)

0.0160*

 Grade 2

15.9

20.2

− 4.3 (− 7.6 to − 1.0)

0.0214*

 Grade 3

13.9

18.2

− 4.2 (− 7.7 to − 0.7)

0.0304*

Ccalc [ml/cmH2O]

    

 Grade 0

35.5

29.3

6.2 (1.0 to 11.3)

0.0325*

 Grade 1

24.9

22.4

2.5 (− 0.9 to 5.9)

0.1728

 Grade 2

20.9

18.7

2.3 (− 1.7 to 6.2)

0.2719

 Grade 3

18.9

16.9

2.0 (− 3.8 to 7.8)

0.5128

R [cmH2O·s/l]

    

 Grade 0

6.3

7.2

− 0.9 (− 2.0 to 0.2)

0.1170

 Grade 1

7.6

8.1

− 0.5 (− 1.4 to 0.5)

0.3396

 Grade 2

9.0

8.9

0.2 (− 0.9 to 1.2)

0.7726

 Grade 3

9.6

9.6

0.0 (− 1.6 to 1.7)

0.9790

PaO2 [mmHg]

    

 Grade 0

118

114

4 (− 6 to 14)

0.4022

 Grade 1

114

107

7 (− 2 to 16)

0.1301

 Grade 2

114

102

12 (− 1 to 25)

0.0918

 Grade 3

116

104

12 (− 1 to 25)

0.0864

PaCO2 [mmHg]

    

 Grade 0

42

42

0 (− 2 to 2)

0.8983

 Grade 1

43

42

1 (− 2 to 4)

0.5619

 Grade 2

43

41

2 (0 to 4)

0.0999

 Grade 3

43

42

2 (− 1 to 4)

0.1916

  1. C displayed compliance from the ventilator, CCalc calculated static compliance, FCV flow-controlled ventilation, IAH intra-abdominal hypertension, MP mechanical power, MV respiratory minute volume, PaCO2 arterial partial pressure of carbon dioxide, PaO2 arterial partial pressure of oxygen, PCV pressure-controlled ventilation, PEEP positive end-expiratory pressure, Pes end-expiratory esophageal pressure, Ppeak peak pressure, R resistance, RR respiratory rate, VT tidal volume, ΔP driving pressure (= peak pressure – positive end-expiratory pressure)
  2. aContinuous data presented as medians
  3. bEstimated median difference for continuous variables
  4. cAssessed by Wilcoxon rank sum test for continuous variables, significant differences (p < 0.05) are marked with an asterisk
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